Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) Pyrazoline

Journal of Tropical Pharmacy and Chemistry

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Title Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) Pyrazoline
 
Creator Khotimah, Nurul
Rahmadani, Agung
Rahmawati, Dewi
Ardana, Mirhansyah
 
Description Pyrazoline is a five-ring heterocyclic compound having 3 carbon atoms and 2 nitrogen atoms known to have some biological activity. This study aims to synthesize 3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) pyrazoline using 2’,4’-dichloro-4-hydroxy-3-methoxy chalcone and hydrazine. Synthesis was performed by reflux method at 80oC for 7 hours. The synthesis compounds were characterized by structural elucidation techniques. From the synthesis results obtained compound 3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) Pyrazoline is pale yellow powder with 84%yield. The result of antioxidant activity test by 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed that the compound had very strong antioxidant activity, Antibacterial test by diffusion method to use paper disk showed that the compound had antibacterial activity against Gram positive bacteria (S.aureus) and Gram negative bacteria (E.coli) and toxicity test by Brine Shrimp Lethality Test (BSLT) showed that the compound had toxicity.
 
Publisher Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117
 
Date 2018-12-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/183
10.25026/jtpc.v4i4.183
 
Source Journal of Tropical Pharmacy and Chemistry; Vol 4 No 4 (2018): Journal of Tropical Pharmacy and Chemistry; 189-193
2407-6090
2087-7099
10.25026/jtpc.v4i4
 
Language eng
 
Relation https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/183/172
 
Rights Copyright (c) 2018 Journal of Tropical Pharmacy and Chemistry
http://creativecommons.org/licenses/by-nc/4.0
 

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