Pharmaceutical Potential of 2’,4’-Dichloro-4-Hydroxy-3-Methoxychalcone Synthesized from Vaniline

Journal of Tropical Pharmacy and Chemistry

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Title Pharmaceutical Potential of 2’,4’-Dichloro-4-Hydroxy-3-Methoxychalcone Synthesized from Vaniline
 
Creator Meilinda, Eka Rizky
Hajrah, Hajrah
Rahmadani, Agung
Rijai, Laode
 
Description Chalcone is an intermediate compound as the main precursor for the biosynthesis of flavonoid in plants. Chalcone has been known to have variety of different pharmacological activities. The difference in chalcone activity is influenced by the differences of subtituents found in both aromatic rings on the chalcone stucture. This study performed the synthesis of 2',4'-dichloro-4-hydroxy-3-methoxychalcone compound from the raw material of 2,4-dichloro acetophenone and vanillin by Claisen-Schmidt reaction using conventional method by stirring. The yield of synthesized compound is 91.57% of purity. The synthesized compounds were characterized by structural elucidation methods using IR, MS, 1H-NMR and 13C-NMR. Toxicity and antioxidant activity tests were performed on the synthesized compound. Base on the test results obtained LC50 value of 20.04 ppm and IC50 26.10 ppm. It is better to describe the pharmaceutical potential of 2',4'-dichloro-4-hydroxy-3-methoxychalcone little bit further.
 
Publisher Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117
 
Date 2018-12-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/181
10.25026/jtpc.v4i4.181
 
Source Journal of Tropical Pharmacy and Chemistry; Vol 4 No 4 (2018): Journal of Tropical Pharmacy and Chemistry; 168-174
2407-6090
2087-7099
10.25026/jtpc.v4i4
 
Language eng
 
Relation https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/181/168
 
Rights Copyright (c) 2018 Journal of Tropical Pharmacy and Chemistry
http://creativecommons.org/licenses/by-nc/4.0
 

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