Direct Spectrophotometric Determination of Cefuroxime Axetil in Pure Form and Pharmaceutical Dosage Forms.

JOURNAL OF ADVANCES IN CHEMISTRY

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Field Value
 
Title Direct Spectrophotometric Determination of Cefuroxime Axetil in Pure Form and Pharmaceutical Dosage Forms.
 
Creator Ramadan, Abdul Aziz
Bakdash, Marwa
 
Description A simple, direct and cost-effective spectrophotometric method for determination of cefuroxime axetil (CRXA)  in pure and tablet dosage forms was applied. This method is based on formation of ion-pair complex ([CRXA]:[BTB]) between CRXA and bromothymol blue (BTB) in chloroform. Beer’s law in the optimum experimental conditions using [CRXA]:[BTB] complex is valid within a concentration range of 2.00-50.00 ?M (1.021–25.524 ?g.mL-1). The developed method is applied for the determination of CRXA in pure and its commercial tablets without any interference from excipients with average assay of 96.8 to 101.6% and the results are in good agreement with those obtained by the HPLC reference method. Associated drugs (sulbactam and linesolid) with cefuroxime axetil are considered to be interfere, while metronidazole can be considered as non-interfere.
 
Publisher KHALSA PUBLICATIONS
 
Date 2018-12-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://cirworld.com/index.php/jac/article/view/7878
10.24297/jac.v15i2.7878
 
Source JOURNAL OF ADVANCES IN CHEMISTRY; Vol 15 No 2 (2018); 6282-6295
2321-807X
 
Language eng
 
Relation http://cirworld.com/index.php/jac/article/view/7878/7556
 
Rights Copyright (c) 2018 JOURNAL OF ADVANCES IN CHEMISTRY
http://creativecommons.org/licenses/by/4.0
 

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