Syzygium aromaticum (CLOVE) EFFECT ON CATALASE ACTIVITY DUE TO CARBON TETRACHLORIDE-INDUCED OXIDATIVE STRESS IN RAT LIVER

Acta Biochimica Indonesiana

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Title Syzygium aromaticum (CLOVE) EFFECT ON CATALASE ACTIVITY DUE TO CARBON TETRACHLORIDE-INDUCED OXIDATIVE STRESS IN RAT LIVER
 
Creator Prijanti, Ani Retno
Hawali, AA
 
Description Background: Clove is known as antioxidant spice that used in cigarettes, spice for food/soup, and traditional medicine. It is believed that clove could protect smokers from cigarette-free radicals. Otherwise, study on clove as an antioxidant was still confused.Objective: To reveal that clove can overcome carbon tetra chloride (CCl4) and its free radical derivesMethod:  This study was an experimental research, using 20 Wistar rats that were divided into 4 groups, Group 1 (CCl4 + cloves 3), group 2 (CCl4 + cloves 1), group 3 (normal control, without being offered treatment), group 4 (positive control, induced by CCl4 and followed by 100 mg alpha-tocopherol), and group 5 (negative control, only induced by CCl4). Rat livers were homogenized and followed with CAT activity measurement using spectrophotometry method of Mates.Results: There was a significant difference in mean between the groups (p= 0,001). Further test, the Post Hoc showed that there is a significance different between group 1 and 4 (p=0.008), 1 and 5 (p=0.001), 2 and 5 (p=0.001), 3 and 5 (p=0.001), and 4 and 5 (p=0.007). Group 1 (CCl4+Clove3) has the highest catalase activity.Conclusion: Syzygium aromaticum (clove) oral administration with the dose of 200 mg/kg rat body weight against 0.55 mg/kgBW CCl4 show increased of catalase activity but did not overcome the oxidative stress.
 
Publisher Acta Biochimica Indonesiana
 
Contributor
 
Date 2018-10-09
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://pbbmi.org/jurnal/index.php/ActaBioIna/article/view/5
 
Source Acta Biochimica Indonesiana; Vol 1, No 1 (2018): ACTA BIOCHIMICA INDONESIANA; 31-36
2654-3222
2654-6108
 
Language eng
 
Relation https://pbbmi.org/jurnal/index.php/ActaBioIna/article/view/5/10
 
Rights Copyright (c) 2018 Acta Biochimica Indonesiana
 

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