The combination of Acalypha indica–Centella asiatica extracts decreases the neuronal damage in hypoxia-induced hippocampal injury animal model

Medical Journal of Indonesia

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Title The combination of Acalypha indica–Centella asiatica extracts decreases the neuronal damage in hypoxia-induced hippocampal injury animal model
 
Creator Farida, Siti; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta
Krisnamurti, Desak G.B.; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta
Mudjihartini, Ninik; Departmen of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta
Purwaningsih, Erni H.; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta
Sianipar, Imelda M.; Department of Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta
Lisnawati, Lisnawati; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta
 
Subject Acalypha indica L.; Centella asiatica L.; dentate gyrus; hypoxia; neurotherapy
 
Description Background: Approximately 80–85% of strokes are ischemic and lead to alterations in neuronal cell morphology and cell death. There is a lack of studies on the effect of the combination of Acalypha indica L. (AI) and Centella asiatica L. (CA) in terms of its neurotherapy property. This study was conducted to investigate the neurotherapeutic effect of the combination of AI–CA extracts in improving rat’s hippocampal neuron injury post-hypoxia.Methods: A total of 36 Sprague-Dawley rats were categorized into six groups and placed in a hypoxia chamber for 7 consecutive days. Then, they were moved to normoxia cages and treated for 7 consecutive days as follows: control group without treatment as a negative control; treatment groups were administered citicoline 50 mg/kgBW as a positive control; three different dose combinations of AI150–CA150, AI200–CA150, and AI250–CA150 mg/kgBW, respectively. Histological analyses were performed to assess the improvement in nerve cell damage in the hippocampus.Results: Treatment with citicoline significantly decreased the damage of nerve cells (30.8%); the combination of the AI–CA extracts of AI150–CA150, AI200–CA150, and AI250–CA150 also significantly decreased the damage of nerve cells (36%, 36.4%, and 30.4%, respectively) compared to the control rats (15.4%).Conclusion: The combination of AI–CA extracts decreased the neuronal damage in the hypoxia-induced hippocampal injury animal model. The improvement effect of the combination of AI–CA extracts was not significantly different to citicoline.
 
Publisher Faculty of Medicine Universitas Indonesia
 
Contributor Universitas Indonesia
 
Date 2018-10-12
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://mji.ui.ac.id/journal/index.php/mji/article/view/1697
10.13181/mji.v27i3.1697
 
Source Medical Journal of Indonesia; Vol 27, No 3 (2018): September; 137-44
2252-8083
0853-1773
10.13181/mji.v27i3
 
Language eng
 
Relation http://mji.ui.ac.id/journal/index.php/mji/article/view/1697/1239
 
Rights Copyright (c) 2018 Siti Farida, Desak G.B. Krisnamurti, Ninik Mudjihartini, Erni H. Purwaningsih, Imelda M. Sianipar, Lisnawati Lisnawati
http://creativecommons.org/licenses/by-nc/4.0
 

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