A double-blind randomized controlled trial of topical Curcuma xanthorrhiza Roxb. on mild psoriasis: clinical manifestations, histopathological features, and K6 expressions

Medical Journal of Indonesia

View Publication Info
 
 
Field Value
 
Title A double-blind randomized controlled trial of topical Curcuma xanthorrhiza Roxb. on mild psoriasis: clinical manifestations, histopathological features, and K6 expressions
 
Creator Rahmayunita, Githa; Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital. Indonesian Psoriasis Study Group, Indonesian Society of Dermatology and Venereology
Jacoeb, Tjut N.A.; Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital. Indonesian Psoriasis Study Group, Indonesian Society of Dermatology and Venereology
Novianto, Endi; Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital. Indonesian Psoriasis Study Group, Indonesian Society of Dermatology and Venereology
Indriatmi, Wresti; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
Rihatmadja, Rahadi; Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital. Indonesian Psoriasis Study Group, Indonesian Society of Dermatology and Venereology
Pusponegoro, Erdina H.D.; Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital. Indonesian Psoriasis Study Group, Indonesian Society of Dermatology and Venereology
 
Subject topical Curcuma xanthorrhiza; psoriasis; PASI; Trozak score K6 expressions
 
Description Background: Curcuma xanthorrhiza Roxb. exerts its anti-inflammatory effects by reducing the concentration of IL-6, IL-8, and phosphorylase kinase, which has role in keratinocyte proliferation. Our study aimed to evaluate the efficacy of C. xanthorrhiza in psoriasis.Methods: From 18 to 59 year-old patients with mild psoriasis, 2 similar lesions were selected. The severity assessment was based on the psoriasis area severity index (PASI), Trozak score, and K6 expression. Using a double-blinded randomized method, lesion was treated with 1% C. xanthorrhiza ointment vs placebo for 4 weeks. The results were analyzed by the chi-square test using STATATM V.12 software (Stata Corp.).Results: The study was conducted in 2010 to 2012 with 17 subjects participated. The median of PASI score were reduced significantly in both lesions, either treated with 1% C. xanthorrhiza ointment vs placebo; however when compared between the group, it was not significant (p=0.520). The Trozak score were reduced in lesions treated with 1% C. xanthorrhiza ointment; but it was not significant (p = 0.306). In lesions treated with placebo, the Trozak score was increased significantly. The difference of Trozak score between lesions treated with C. xanthorrhiza and placebo was significant (p=0.024). There was no significant difference of K6 expression in lesions treated with 1% C. xanthorrhiza ointments or placebo as well as on the difference of mean values of K6 expression between the group (p=0.827).Conclusion: Based on the results, 1% C. xanthorrhiza ointment is effective treatment option for mild psoriasis, but longer follow-up period is suggested to confirm this results. C. xanthorrhiza ointment is safe for topical administration as there were no side effects reported in this study.
 
Publisher Faculty of Medicine Universitas Indonesia
 
Contributor Yayasan Peduli Psoriasis Indonesia, Dr. dr. Nurjati Siregar, SpPA from Anatomic Pathology Department of Ciptomangunkusumo Hospital, PT Soho Industri Pharmasi
 
Date 2018-10-12
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://mji.ui.ac.id/journal/index.php/mji/article/view/2511
10.13181/mji.v27i3.2511
 
Source Medical Journal of Indonesia; Vol 27, No 3 (2018): September; 178-84
2252-8083
0853-1773
10.13181/mji.v27i3
 
Language eng
 
Relation http://mji.ui.ac.id/journal/index.php/mji/article/view/2511/1245
 
Rights Copyright (c) 2018 Githa Rahmayunita, Tjut N.A. Jacoeb, Endi Novianto, Wresti Indriatmi, Rahadi Rihatmadja, Erdina H.D. Pusponegoro
http://creativecommons.org/licenses/by-nc/4.0
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library