Antidiabetic and Immunomodulatory Effects of Oleuropein and Vitamin C in Diabetic Male Rats

JOURNAL OF ADVANCES IN BIOLOGY

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Field Value
 
Title Antidiabetic and Immunomodulatory Effects of Oleuropein and Vitamin C in Diabetic Male Rats
 
Creator Mohamed, Nema Abdelhameed
Abdou, Heba Mohamed
Marzouk, Marium Mohamed
 
Description The present work was designed to study the antidiabetic and immunomodulatory effects of olive leaf polyphenol (Oleuropein) and vitamin C in diabetic male rats. Diabetes was induced by a single i.p. dose of STZ (40 mg/kg b.w.). Pure oleuropein compound (5 mg/kg b.w.) and vit. C (150 mg/kg b.w.) were orally administered once per a day for 15 days after diabetes induction. Oleuropein and vitamin C showed a significant role in attenuating the blood glucose, insulin, pancreatic amylase, and hexokinase alterations and caused an elevation of antioxidant enzymes in diabetic rats. Oleuropein and vitamin C showed a hematopoetic action as documented by the increase in RBC, Hb, Hct, PLt, decrease in WBC and improved RBC structure. Oleuropein and vitamin C significantly attenuated the oxidative status of diabetic rats. Oleuropein and vitamin C improved the different changes in some cytokines and interlukines and decreases the gene expression of TNF-, COX2, and caspase3 involved in apoptosis and inflammation. The immunohistochemical sections of pancreas in the diabetic rats treated with oleuropein and vitamin C showed a high intensity of insulin in -cells. Oleuropein as a natural active compound has antioxidant activity more or less like vitamin C to attenuate the effect of STZ-induced diabetes.
 
Publisher KHALSA PUBLICATIONS
 
Date 2018-10-04
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
reviewed Article
 
Format application/pdf
 
Identifier http://cirworld.com/index.php/jab/article/view/7689
10.24297/jab.v11i0.7689
 
Source JOURNAL OF ADVANCES IN BIOLOGY; Vol 11 (2018): Advances in Biology; 2250-2268
2347-6893
 
Language eng
 
Relation http://cirworld.com/index.php/jab/article/view/7689/7478
 
Rights Copyright (c) 2018 JOURNAL OF ADVANCES IN BIOLOGY
http://creativecommons.org/licenses/by/4.0
 

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