Phase Diagram and Thermodynamic Properties of Ketoprofen-Succinic Acid Binary Mixtures

Jurnal ILMU DASAR

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Field Value
 
Title Phase Diagram and Thermodynamic Properties of Ketoprofen-Succinic Acid Binary Mixtures
 
Creator Wicaksono, Yudi
Setyawan, Dwi
Siswandono, S.
 
Description The equilibrium phase diagram and thermodynamic properties of a mixture of drugs and additives are information related to various possible interaction processes between components. Therefore, we conducted a study of the phase diagrams and thermodynamic properties of binary mixtures of ketoprofen-succinic acid to estimate the types of interactions that may occur between these materials. The solid-liquid phase diagram of ketoprofen-succinic acid binary mixtures was determined by differential scanning calorimetry and composition of eutectic system was determined accurately using a Tamman diagram. The measurement of binary mixtures of ketoprofen-succinic acid with differential scanning calorimeter obtained the value of melting temperature and heat of fusion of ketoprofen- succinic acid system. The solid-liquid phase diagram of ketoprofen- succinic acid showed the formation of eutectic type phase diagram. The Tamman diagram showed accurately composition of the eutectic system of the Kp-SA binary mixtures at the mole fraction of Kp 0.87 and temperature 96.9oC.Keywords: ketoprofen, phase diagram, eutectic system, Tamman diagram
 
Publisher Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember
 
Date 2018-07-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://jurnal.unej.ac.id/index.php/JID/article/view/5521
10.19184/jid.v19i2.5521
 
Source Jurnal ILMU DASAR; Vol 19 No 2 (2018); 99-104
2442-5613
1411-5735
 
Language eng
 
Relation https://jurnal.unej.ac.id/index.php/JID/article/view/5521/5695
 
Rights Copyright (c) 2018 Yudi Wicaksono, Dwi Setyawan, S. Siswandono
http://creativecommons.org/licenses/by-sa/4.0
 

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