Relationship between Trans-Membrane Protease Serine 6 Gene Polymorphism (C1795T) and Danger of Iron Deficiency Anemia in Khartoum State-2019

Jurnal Perspektif Pembiayaan dan Pembangunan Daerah

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Title Relationship between Trans-Membrane Protease Serine 6 Gene Polymorphism (C1795T) and Danger of Iron Deficiency Anemia in Khartoum State-2019
 
Creator Homri, Najla H.
Abdalla, Selma E.
Hamid, Tarig Altayb
 
Description Iron deficiencies anemia has been broadly discovered and understood as a nutritional disorder but there is a limited understanding of iron deficiency anemia, which is due to genetic alterations in iron homeostasis, which is a recently recognized recessive disorder that causes microcytic hypochromic anemia. It’s due to mutations in the trans-membrane protease serine 6 genes (C1795T), which encodes matriptase-2, and mainly expressed by hepatocytes. In this analytical study case- control, we registered hundred patients with iron deficiency anemia and 100 healthy volunteers as a control group and analyzed their complete blood counts and TMPRSS6 genotypes. TMPRSS6 C/T polymorphism was analyzed using polymerase chain reaction. The TT genotype (mutant gene) of TMPRSS6 C1795T polymorphism was higher frequent in IDA patients (71.4%). The results show low hemoglobin concentration and MCV while RDW was increase significant difference (P≤0.00) in IDA patients compare with normal individual when interacted with the TMPRSS6 genotypes. In peroration there were statistically significant association between TMPRSS6 C/T polymorphism and risk of IDA among Sudanese patients in Khartoum state.Hematology
 
Publisher Scholar Science Journals
 
Date 2020-01-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://ssjournals.com/index.php/ijbr/article/view/5249
10.7439/ijbr.v10i12.5249
 
Source International Journal of Biomedical Research; Vol 10 No 12 (2019): Dec; e5249
0976-9633
2455-0566
 
Language eng
 
Relation https://ssjournals.com/index.php/ijbr/article/view/5249/3622
 
Rights Copyright (c) 2019 International Journal of Biomedical Research
http://creativecommons.org/licenses/by/4.0
 

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