Effect of zinc supplementation on triglyceride and malondialdehyde levels: study on diabetic Wistar rats induced with streptozotocin

Medical Journal of Indonesia

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Title Effect of zinc supplementation on triglyceride and malondialdehyde levels: study on diabetic Wistar rats induced with streptozotocin
Creator Ryadinency, Resty; Department of Public Health Nutrition, STIKES Mega Buana Palopo, Sulawesi Selatan
Hadisaputro, Suharyo; Department of Public Health, Faculty of Medicine, Universitas Diponegoro, Semarang
Rachmawati, Banundari; Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang
Subject fasting blood glucose; diabetes mellitus; MDA; triglycerides; zinc
Description Background: Diabetes mellitus is associated with increased blood glucose and triglyceride levels, which can lead to an oxidative stress. Zinc (Zn) is a micronutrient that has antioxidant properties and involved in lipid and glucose metabolism. This study aimed to evaluate the effect of zinc on the levels of fasting blood glucose (FBG), triglycerides (TG), and malondialdehyde (MDA) in male diabetic Rattus norvegicus Wistar rats.Methods: Diabetes was induced by intraperitoneal (i.p.) injection of 40 mg/kg BW streptozotocin (STZ) and confirmed by FBG level higher than 200 mg/dL after 2 weeks. The rats were randomly divided into three groups: control group (STZ), treatment I (STZ + zinc 5 mg/kg BW), and treatment II (STZ + zinc 10 mg/kg BW). Zinc was administered by oral gavage for 30 days. At the end of the experiment, levels of FBG, TG, and MDA were measured. Data were analyzed using paired t-test or Wilcoxon test as appropriate.Results: Supplementation of 5 mg/kg zinc significantly decreased the levels of FBG (pre-intervention: 328.95±70.90 mg/dL, post-intervention: 144.35±34.27 mg/dL, p<0.05), TG (pre-intervention: 252.48±26.30 mg/dL, post-intervention: 147.90±12.18 mg/dL, p<0.05), and MDA (pre-intervention: 12.11±6.46 nm/mL, post-intervention: 4.75±2.34 nm/mL, p<0.05). Moreover, supplementation of 10 mg/kg zinc decreased the levels of TG (pre-intervention: 275.62±56.25nm/mL, post-intervention: 165.58±22.63 nm/mL, p<0.05) and MDA (pre-intervention: 13.08±6.60 nm/mL, post-intervention: 5.08±2.40 nm/mL, p<0.05).Conclusion: Supplementation of zinc significantly reduced the levels of FBG, TG, and MDA in diabetic rats.
Publisher Faculty of Medicine Universitas Indonesia
Date 2018-09-09
Type info:eu-repo/semantics/article

Format application/pdf
Identifier http://mji.ui.ac.id/journal/index.php/mji/article/view/1417
Source Medical Journal of Indonesia; Vol 27, No 2 (2018): June; 82–6
Language eng
Relation http://mji.ui.ac.id/journal/index.php/mji/article/view/1417/1230
Rights Copyright (c) 2018 Resty Ryadinency, Suharyo Hadisaputro, Banundari Rachmawati

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