Aktivitas Inhibitor Alfa-Amilase Beberapa Tumbuhan Obat Indonesia

Jurnal Sains dan Kesehatan

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Title Aktivitas Inhibitor Alfa-Amilase Beberapa Tumbuhan Obat Indonesia
Creator Rijai, Akhmad Jaizzur
Suganda, Asep Gana
Iskandar, Elin Yulinah
Description Diabetes and its complication was major causes of death in most countries compared HIV/AIDS, tuberculosis and malaria. One approach in the treatment of diabetes is by slowing down the glucose absorption in the gastrointestinal tract, its can be achieved by inhibition of hydrolizing enzymes such as α-amylase so the absorption of glucose becomes slow. This research aim was to determine the α-amylase inhibitor activity from aqueous extract from some tradicional medicine plant such as daun insulin (Smallanthus sonchifolius (Poepp.) H.Rob), kembang bulan (Tithonia diversifolia (Hemsl.) Gray), bodhi leaf (Ficus religiosa L.), and Mahogany seeds (Swietenia mahagoni (L.) Jacq.). Extraction was done by reflux method using aquadest as a solvent. Extracts were obtained by freeze drying and tested for α-amylase inhibitory activities. The IC50 value of daun insulin (EADI), kembang bulan leaf (EADKB), bodhi leaf (EADB) mahogany seeds (EABM) aqueous extract and acarbose as reference were 282,53; 473,85; 423,01; 220,91; and 3,42 μg / mL, respectively.
Keywords: alfa-amylase, traditional medicine plant, diabetes, IC50 and aqueous extract.
Publisher Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia
Date 2018-07-01
Type info:eu-repo/semantics/article
Peer-reviewed Article
Format application/pdf
Identifier https://jsk.farmasi.unmul.ac.id/index.php/jsk/article/view/97
Source Jurnal Sains dan Kesehatan; Vol 1 No 10 (2018): Jurnal Sains dan Kesehatan; 517-524
Language eng
Relation https://jsk.farmasi.unmul.ac.id/index.php/jsk/article/view/97/87
Rights Copyright (c) 2018 Jurnal Sains dan Kesehatan

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