APHRODISIAC ACTIVITY OF ETHANOL EXTRACT OF Cratoxylum sumatranum (JACK) BLUME STEMS ON ISOLATED RAT CORPUS CAVERNOSUM

Journal of Tropical Pharmacy and Chemistry

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Title APHRODISIAC ACTIVITY OF ETHANOL EXTRACT OF Cratoxylum sumatranum (JACK) BLUME STEMS ON ISOLATED RAT CORPUS CAVERNOSUM
 
Creator Ismail, Sjarif
Aminyoto, Meiliati
 
Description Cratoxylum sumatranum (Jack) Blume of the Hypericaceae family is known as “Bentaleng†by Dayak Benuaq. In ethnobotany, Cratoxylum sumatranum stems (CSS) is used as energy drink or aphrodisiac, but its effect has not been scientifically proven. Research objective to study the aphrodisiac activity of CSS extract by screening the aphrodisiac activity in vitro. Method: CSS was collected from Kutai Kertanegara Regency, East Kalimantan Province. Extraction was by maceration with ethanol solvent for three days. Re-maceration was done twice. In vitro screening of aphrodisiac activity used isolated rat corpus cavernosum. The organ was placed into a 10 mL chamber containing Krebs-Henselheit solution at pH 7.4, 37°C and aerated with carbogen gas. After acclimation, a contraction test was performed with phenylephrine solution and after reaching the peak of contraction at plateau the Control (solvent extract) or CSS ethanol extract was administerd at cumulatively increased concentration. Vasodilation activity was known if the contraction response was decreased after the extract’s administration and expressed in percent contraction with negative value. Results: CSS ethanol extract induce vasodilatory response on rat Corpus cavernosum blood vessels. Vasodilation activity is increasing with increasing concentration of extract given compared to Control. Conclusion the aphrodisiac activity of CSS ethanol extracts is directly through the vasodilation action mechanism on blood vessels in the rat corpus cavernosum.  
 
Publisher Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117
 
Date 2018-07-26
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/150
10.25026/jtpc.v4i3.150
 
Source Journal of Tropical Pharmacy and Chemistry; Vol 4 No 3 (2018): Journal of Tropical Pharmacy and Chemistry; 122-127
2407-6090
2087-7099
10.25026/jtpc.v4i3
 
Language eng
 
Relation https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/150/153
 
Rights Copyright (c) 2018 Journal of Tropical Pharmacy and Chemistry
http://creativecommons.org/licenses/by-nc/4.0
 

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