The Curative Effect of Berberine Nanoparticles and Cisplatin Combination Therapies Against Hepatocarcinogenesis-Induced By N-Nitroso-Diethylamine In Male Rat

JOURNAL OF ADVANCES IN BIOLOGY

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Title The Curative Effect of Berberine Nanoparticles and Cisplatin Combination Therapies Against Hepatocarcinogenesis-Induced By N-Nitroso-Diethylamine In Male Rat
 
Creator Mohamed, Nema Abdelhameed
Ali, Awatef Mohamed
Ghareeb, Doaa Ahmed
Mohamed, Adham Rashed
Elmokhtar, Yasmin Mohamed
 
Description This study aimed to investigate whether berberine nanoparticles (BBR-NPs) and/or cisplatin supplementation could prevent hepatocarcinogenesis-induced by N-nitroso-diethylamine (DENA) in male rats. Male Wistar albino rats were divided into five groups; Group 1: Control; Group 2: DENA-CCl4; Group 3: DENA-CCl4+Cisplatin; Group 4: DENA-CCl4+BBR-NPs; Group 5: DENA-CCl4+Cisplatin+BBR-NPs. DENA-CCl4 significantly increase AST, ALT, ALP, LDH, GGT, AFP activities and total bilirubin, while, 5, NT,  total protein and albumin decreased. DENA-CCl4 treatment caused increment in MDA levels and reduction in SOD, CAT, GPx and GSH in liver tissues. Moreover, DENA-CCl4 increase the gene expression of ADAM17 and TNF-a however,  P53 was declined. In addition, DENA-CCl4 caused severe histopathological lesions in the liver tissue. Interestingly, administration of berberine nanoparticles alone or in combination with cisplatin improves the hepatocarcinogenesis induced by DENA-CCl4 on the physiological, biochemical, molecular and histological levels by decreasing oxidative stress and preserving gene expression of ADAM17, TNF-I and P53. The present findings suggest that BBR-NPs with cisplatin might offer a promising strategy for the prevention of liver cancer.
 
Publisher KHALSA PUBLICATIONS
 
Date 2018-04-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
reviewed Article
 
Format application/pdf
 
Identifier http://cirworld.com/index.php/jab/article/view/7207
10.24297/jab.v11i1.7207
 
Source JOURNAL OF ADVANCES IN BIOLOGY; Vol 11 (2018): Advances in Biology; 2180-2200
2347-6893
 
Language eng
 
Relation http://cirworld.com/index.php/jab/article/view/7207/7112
 
Rights Copyright (c) 2018 JOURNAL OF ADVANCES IN BIOLOGY
http://creativecommons.org/licenses/by/4.0
 

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