Quality control and standardization of FACA® syrup

International Journal of Drug Delivery

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Title Quality control and standardization of FACA® syrup
 
Creator Ouedraogo, Salfo; Département Médecine Pharmacopée Traditionnelles et Pharmacie, Institut de Recherche en Sciences de la Santé (MEPHATRA-PH /IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso.
Traoré, Sidiki; Département Médecine Pharmacopée Traditionnelles et Pharmacie, Institut de Recherche en Sciences de la Santé (MEPHATRA-PH /IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso.
Ouédraogo, Jean Claude W.; Département Médecine Pharmacopée Traditionnelles et Pharmacie, Institut de Recherche en Sciences de la Santé (MEPHATRA-PH /IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso.
Koala, Moumouni; Département Médecine Pharmacopée Traditionnelles et Pharmacie, Institut de Recherche en Sciences de la Santé (MEPHATRA-PH /IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso.
Belemnaba, Lazare; Département Médecine Pharmacopée Traditionnelles et Pharmacie, Institut de Recherche en Sciences de la Santé (MEPHATRA-PH /IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso.
Ouédraogo, Noufou; Département Médecine Pharmacopée Traditionnelles et Pharmacie, Institut de Recherche en Sciences de la Santé (MEPHATRA-PH /IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso.
Kini, Felix; Département Médecine Pharmacopée Traditionnelles et Pharmacie, Institut de Recherche en Sciences de la Santé (MEPHATRA-PH /IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso.
Ouédraogo, Sylvin; Département Médecine Pharmacopée Traditionnelles et Pharmacie, Institut de Recherche en Sciences de la Santé (MEPHATRA-PH /IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso.
Guissou, Innocent Pierre; 1. Département Médecine Pharmacopée Traditionnelles et Pharmacie, Institut de Recherche en Sciences de la Santé (MEPHATRA-PH /IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso. 2. Laboratoire de Pharmacologie-Toxicologie/Unité de Formation et de Recherche en Sciences de la Santé (UFR/SDS), Université de Ouagadougou, 03 BP 7021 Ouagadougou 03, Burkina Faso.
 
Subject Pharmaceutical Sciences
FACA syrup, sickle cell disease, plant powder, medicinal plant, quality control
 
Description Sickle cell disease is a major public health problem. It is the first genetic disease in the world. FACA syrup offers an alternative treatment. It is a dry powder preparation of two components, the roots barks of Zanthoxylum zanthoxyloides Lam. (Rutaceae) Zepernick, Timler and Calotropis procera. Ait. R.B.r. (Asclepiadaceae). The product was developed at Institute for Research in Health Sciences (IRSS) from a traditional recipe used in Burkina Faso for treatment of sickle cell crises. This study aimed to establish physical-chemical, pharmaco technical and microbiological control parameters essential for the standardization of the phytomedicine. This valuation concerned specifications of moisture content, pH, the fingerprint by thin layer chromatography, pesticide residues, heavy metal content, microbial quality, and total ash. These charcteristics were determined by the methods prescribed by the World Health Organization (1998) and the European Pharmacopoeia 6th edition. The results have shown that dry syrups and reconstituted syrups were sweet, slightly spicy with a bitter after taste, a white room color and a faint odor. The density at the preparation was 0.985 and the pH was 5.93. After 2 months of storage in the laboratory, the organoleptic parameters of the reconstituted syrups have not changed. They were mold free, the density remained around 1 and the pH between 5 and 4. These parameters have shown that the quality of plants powders and these medicine comply with the recommendations of the European pharmacopoeia. Faca syrup may contribute to the better management of sickle cell disease in children.
 
Publisher Advanced Research Journals
 
Contributor Pr Innocent Pierre Guissou
 
Date 2018-01-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/2166
10.5138/09750215.2166
 
Source International Journal of Drug Delivery; Vol 9, No 4 (2017): International Journal of Drug Delivery; 101-106
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/2166/pdf
 
Rights Copyright (c) 2017 Salfo OUEDRAOGO
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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