In vitro evaluation of Transdermal Patch of Palonosetron for Antiemetic Therapy

International Journal of Drug Delivery

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Field Value
 
Title In vitro evaluation of Transdermal Patch of Palonosetron for Antiemetic Therapy
 
Creator Tripathi, Atul; University Institute of Pharmacy Pt. Ravishankar Shukla University Raipur (C.G.) 492 010, INDIA
Tyagi, Piyush; College of Pharmacy, SSSUTMS, Sehore, M.P.
Vyas, Amber; University Institute of Pharmacy Pt. Ravishankar Shukla University Raipur (C.G.) 492 010, INDIA
Gidwani, Beena; University Institute of Pharmacy Pt. Ravishankar Shukla University Raipur (C.G.) 492 010, INDIA
Chandekar, Amol; School of Pharmacy & Research, Peoples University, Bhopal
Sharma, Hemant kumar; College of Pharmacy, SSSUTMS, Sehore, M.P.
 
Subject Pharmaceutical Sciences; Pharmaceutics; Drug Delivery
Palonosetron; Transdermal Drug Delivery System; Serotonin 5-HT3 antagonist
 
Description Skin is one of the routes for systemic delivery of drugs through various drug delivery system. A transdermal Drug Delivery System (TDDS) is one of the most reliable and useful system to deliver drug systemically through skin. Generally medicated patch is placed on skin for delivery of medication through it into the blood stream. The aim of present study was to formulate and evaluate Palonosetron transdermal patch in vitro that could be used for antiemetic therapy. The incorporation ofPalonosetron a serotonin 5-HT3 antagonist drug was envisaged. The TDDS was prepared by solvent evaporation technique and was evaluated for organoleptic characteristics and other physicochemical properties Thickness, Weight variation, Drug content uniformity, Tensile strength, % Elongation, Folding endurance & Moisture content. The in vitro permeation study of the patch was carried out through KesaryChein diffusion cell as barrier membrane. Phosphate buffer pH 7.4 was used as dissolution medium and the temperature was maintained at 37 ± 10C. The in vitro permeation study of the prepared patch indicated a time dependent increase in drug release throughout the study. The percentage of cumulative drug release was found to be 76.25% in 24 hours.The study shows a new approach to work in with Palonosetron.
 
Publisher Advanced Research Journals
 
Contributor
 
Date 2018-01-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/2186
10.5138/09750215.2186
 
Source International Journal of Drug Delivery; Vol 9, No 4 (2017): International Journal of Drug Delivery; 119-124
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/2186/pdf
 
Rights Copyright (c) 2017 Atul Tripathi; Piyush Tyagi; Amber Vyas; Beena Gidwani; Amol Chandekar; Hemant kumar Sharma
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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