A STUDY ON THE INCIDENCE OF STRESS HAZARDS RELATIVE TO ALLOSTATIC LOAD AMONG HEALTHY VOLUNTEER IN INDIA

IJAR - Indian Journal of Applied Research

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Title A STUDY ON THE INCIDENCE OF STRESS HAZARDS RELATIVE TO ALLOSTATIC LOAD AMONG HEALTHY VOLUNTEER IN INDIA
 
Creator Thomas, Abhilash; Department of Pharmacy Practice, Oxbridge College of Pharmacy, Bengaluru, India *Corresponding Author
Hiremath, Jagadeesh G.; Department of Pharmaceuitics, Oxbridge College of Pharmacy, Bengaluru, India
KM, Poornajith; Department of Psychiatry, The Government Head Quarters Hospital, Ooty, India
Samanta, Malay Kumar; Department of Pharmaceutical Biotechnology, J.S.S. College of Pharmacy, Ooty, India
 
Subject
 
Description Introduction: The objective of this study was to assess the stress hazards in respective to Allostatic load factors in Indian human volunteers. The benefits of establishing the relation of Allostatic load and vital body physiological functions would be helpful in measuring drug effectiveness. Methods: The Perceived Stress Scale 10 (PSS 10) was used to measure the stress levels. The Allostatic load factors such as Epinephrine, Norepinephrine, Dopamine and Cortisol were measured from urine and serum samples. The physiological vitals like blood pressure (BP), heart rate (HR), respiratory rate (RR) and body temperature were also measured manually. Results: The Allostatic load factors were found to be elevated with increased stress. The primary mediators of Allostatic; Epinephrine, Norepinephrine and Cortisol were elevated (p<0.05) with increased stress while Dopamine changes were little. The secondary mediators systolic blood pressure (134.17±5.15, p<0.05) and diastolic blood pressure (87.54±8.67, p<0.05) were high. The heart rate and respiratory rate were increased but body temperature had not altered. Conclusion: The Allostatic load factors can be used as better predictors of altered physiological functions. This shall be extrapolated to rate of drug metabolism during stress exposure. The study recommends further studies with repeated samples to prove this hypothesis.
 
Publisher World Wide Journals
 
Contributor
 
Date 2017-10-28
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://worldwidejournals.in/ojs/index.php/ijar/article/view/10
 
Source IJAR - Indian Journal of Applied Research; Vol 7, No 10 (2017): October
2249 - 555X
 
Language eng
 
Relation http://worldwidejournals.in/ojs/index.php/ijar/article/view/10/10
http://worldwidejournals.in/ojs/index.php/ijar/article/downloadSuppFile/10/11
 
Rights Copyright (c) 2017 Abhilash Thomas, Jagadeesh G. Hiremath, Poornajith KM, Malay Kumar Samanta
http://creativecommons.org/licenses/by/4.0
 

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