Nanoparticle preparation and characterization of Haruan fish (Channa striata) exctract contains albumin from south Kalimantan with ionic gelation method

International Journal of Drug Delivery

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Title Nanoparticle preparation and characterization of Haruan fish (Channa striata) exctract contains albumin from south Kalimantan with ionic gelation method
 
Creator D, Rahmawanty; Pharmacy Department, Faculty of Mathematics and Natural Science, Universitas Lambung Mangkurat, Indonesia
A, Risa; Pharmacy Department, Faculty of Mathematics and Natural Science, Universitas Lambung Mangkurat, Indonesia
N, Malikhatun; Pharmacy Department, Faculty of Mathematics and Natural Science, Universitas Lambung Mangkurat, Indonesia
HR, Prima; Pharmacy Department, Faculty of Mathematics and Natural Science, Universitas Lambung Mangkurat, Indonesia
K, Nani; Pharmacy Department, Faculty of Mathematics and Natural Science, Universitas Lambung Mangkurat, Indonesia
A, Effionora; Faculty Of Pharmacy, Universitas Indonesia
 
Subject Pharmaceutical Sciences
ionic gelation, nanoparticle, snakehead fish (Channa striata)
 
Description Snakehead fish (Channa striata) has been reported to be used for wound healing by people in South Borneo because it contains albumin. Snakehead fish extract (Channa striata) has hydrophillic property and poor stability. Nanoparticle technology has been started to be developed as an alternative solution to improve drug delivery profile. The purpose of this study was to determine the formulation that obtained best characterization for nanoparticle. Nanoparticles were prepared by ionic gelation method, that was prepared by doing optimize ratio between snakehead fish extract : chitosan and pH of chitosan solvent.Nanoparticles were characterized using Particle Size Analyzer for particle size and particle size distribution, measurement of entrapment efficiency, determined Zeta potential using Particle Size Analyzer, and observation of particle’s morphology using Transmission Electron Microscope. The result showed that the chosen formula was formula 6 which  ratio of extract : chitosan 1:2 with chitosan solvent pH 3, particle size 152.3 nm, polidispersity index 0.778, percentage of entrapment efficiency 51.3961 %, Zeta potential +35.9 mV, and round shape of particles.
 
Publisher Advanced Research Journals
 
Contributor Directorate General of Higher Education, The Ministries Of Research, Technology, And Higher Education Republic Of Indonesia
 
Date 2017-10-06
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/2070
10.5138/09750215.2070
 
Source International Journal of Drug Delivery; Vol 9, No 2 (2017): International Journal of Drug Delivery; 47-51
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/2070/pdf
 
Rights Copyright (c) 2017 dina rahmawanty
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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