Synthesis and in vitro drug release studies on substituted polyphosphazene conjugates of lumefantrine.

International Journal of Drug Delivery

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Field Value
 
Title Synthesis and in vitro drug release studies on substituted polyphosphazene conjugates of lumefantrine.
 
Creator Kumar, Sahil; School of Pharmacy & Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi-173205, India
Sharma, Alka; School of Pharmacy & Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi-173205, India
Singh, Rajesh K; Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Distt. Roopnagar, Punjab, 140126, India
Prasad, DN; Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Distt. Roopnagar, Punjab, 140126, India
Bhardwaj, TR; School of Pharmacy & Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi-173205, India
 
Subject Pharmaceutical Sciences; Pharmaceutics; Drug Delivery
polyphosphazene, lumefantrine, conjugate, malaria, p-amino benzoic acid ester.
 
Description The present study pertains to the delivery of antimalarial drug (Lumifantrine). In this, polyphosphazene has been used in the synthesis of polyphosphazene-linked conjugates of Lumifantrine. These polymer-linked Conjugates have been synthesized and characterized by modern analytical techniques. The in-vitro drug release of Lumifantrine drug conjugates: p-Amino benzoic acid ester substituted polyphosphazene drug conjugate (15) and Glycine methyl ester substituted polyphosphazene drug conjugate (21) have been found to be 6.00 % and 5.96% (pH 1.2), 88.52% and 79.86% (pH 7.4), respectively. These drug conjugate may prove an effective delivery system for the treatment of malaria.
 
Publisher Advanced Research Journals
 
Contributor
 
Date 2017-10-06
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/2133
10.5138/09750215.2133
 
Source International Journal of Drug Delivery; Vol 9, No 2 (2017): International Journal of Drug Delivery; 36-46
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/2133/pdf
 
Rights Copyright (c) 2017 Sahil Kumar, Alka Sharma, Rajesh K Singh, DN Prasad, TR Bhardwaj
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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