Formulations and evaluation of Cyclodextrin complexed Ceadroxil loaded nanosponges

International Journal of Drug Delivery

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Title Formulations and evaluation of Cyclodextrin complexed Ceadroxil loaded nanosponges
 
Creator Dubey, Pawan; College of Pharmacy, Sri SatyaSai University of Technology and Medical Sciences, Sehore, M.P.
Sharma, Hemant Kumar; College of Pharmacy, Sri SatyaSai University of Technology and Medical Sciences, Sehore, M.P.
Shah, Sunil; College of Pharmacy, Sri SatyaSai University of Technology and Medical Sciences, Sehore, M.P.
Tyagi, Chandra Kishore; College of Pharmacy, Sri SatyaSai University of Technology and Medical Sciences, Sehore, M.P.
Chandekar, Amol R.; School of Pharmacy & Research, People's University , Bhopal, M.P.
Jadon, Rajesh S.; SoS in Pharmaceutical Sciences, Jiwaji University, Gwalior, MP, India
 
Subject Pharmaceutical Sciences; Pharmaceutics; Drug Delivery
Cefadroxil; cyclodextrins; nanosponges; paracrystalline;
 
Description Cefadroxil (CFD) is a broad spectrum antibiotic that acts against an extensive variety of bacteria, including Gram-positive and Gram-negative bacteria. The major drawback of orally administered drug like cefadroxil is its shorter half life of 1.2 hrs. The goal of the study is to prolong the drug release, producing a desired blood serum level, reduction in drug toxicity and improving the patient compliance by prolonging the dosing intervals. Cyclodextrin-based nanosponges (NS) are a novel class of cross-linked derivatives of cyclodextrins. They have been used to increase the solubility of poorly soluble actives, to protect the labile groups and control the release. This study aimed at formulating complexes of CFDwith three types of β-cyclodextrin NS obtained with different cross-linking ratio (viz. 1:2, 1:4 and 1:8 on molar basis with the cross-linker) to protect the lactone ring from hydrolysis and to prolong the release kinetics of CFD. Crystalline (F1:2, F1:4 and F1:8) and paracrystalline NS formulations were prepared. XRPD, DSC and FTIR studies confirmed the interactions of CFDwith NS. XRPD showed that the crystallinity of CFD decreased after loading. CFD was loaded as much as 21%, 37% and 13% w/w in F1:2 , F1:4 and F1:8, respectively while the paracrystalline NS formulations gave a loading of about 10% w/w or lower. The particle sizes of the loaded NS formulations were between 450 and 600 nm with low polydispersity indices. The zeta potentials were sufficiently high (-20 to -25 mV) to obtain a stable colloidal nanosuspension. The in vitro studies indicated a slow and prolonged CFD release over a period of 24 h. The NS formulations protected the lactone ring of CFD after their incubation in physiological conditions at 37°C for 24 h with a 80% w/w of intact lactone ring when compared to only around 20% w/w of plain CFD.
 
Publisher Advanced Research Journals
 
Contributor
 
Date 2017-10-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/2180
10.5138/09750215.2180
 
Source International Journal of Drug Delivery; Vol 9, No 3 (2017): International Journal of Drug Delivery; 84-100
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/2180/pdf
 
Rights Copyright (c) 2017 Pawan Dubey, Hemant Kumar Sharma, Sunil Shah, Chandra Kishore Tyagi, Amol R. Chandekar, Rajesh S. Jadon
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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