In vitro cytotoxicity, in vivo pharmacokinetic studies and tissue distribution studies of multifunctional citric acid dendrimers using the drug Cytarabine

International Journal of Drug Delivery

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Field Value
 
Title In vitro cytotoxicity, in vivo pharmacokinetic studies and tissue distribution studies of multifunctional citric acid dendrimers using the drug Cytarabine
 
Creator Reddy, K Ravindra; Dept. of Pharmaceutics, CES college of Pharmacy, Kurnool, AP.
Rao, B Narasimha; Dept. of Pharmaceutics, P Rami Reddy Memorial College of Pharmacy, Kadapa, AP.
Sekhar, KB Chandra; Oil Technological Research Institute, JNTUA, Anantapuramu, AP.
 
Subject Pharmaceutical Sciences; Pharmaceutics; Drug Delivery
Citric acid, Cytarabine, Dendrimers, Leukemia, PEGylation, Tumor.
 
Description Dendrimers are considered the emerging polymeric architectures, known for their well defined molecular-weight, polydispersity, uniformity and high-surface functionality. These nano-architectures are capable of encapsulating low-high molecular-weight drug moieties in their interior or exterior through covalent bonding and host-guest interactions. Further, large surface volume made researchers to implicate dendrimers in biomedical and therapeutic applications. Regardless of the massive applications, sometimes its use is limited because of the cytotoxicity produced.  Considering this, the present research is focused on the synthesis and PEGylation of citric acid dendrimers. PEGylation is an act of conjugating polyethylene glycol to dendrimers that completely eliminates the toxicity issues associated with dendrimers and render them biocompatible. Cytarabine was loaded in the dendritic architecture to target specifically the tumor cells. Dendrimers are made tumor specific by incorporating certain agents that get cleaved in tumor environment. Synthesized dendrimers were studied for its effect on acute cytotoxicity, tissue-distributions and pharmacokinetic parameters.
 
Publisher Advanced Research Journals
 
Contributor
 
Date 2017-10-06
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/2128
10.5138/09750215.2128
 
Source International Journal of Drug Delivery; Vol 9, No 2 (2017): International Journal of Drug Delivery; 28-35
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/2128/pdf
 
Rights Copyright (c) 2017 K Ravindra Reddy, B Narasimha Rao, KB Chandra Sekhar
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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