Investigations on noval method for the formulation of solid dispersions part- I Formulation, characterization and selection

International Journal of Drug Delivery

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Field Value
 
Title Investigations on noval method for the formulation of solid dispersions part- I Formulation, characterization and selection
 
Creator Sharma, Rakesh Kumar; School of pharmacy Opjs university, churu Rajasthan India
Middha, Anil Kumar; School of pharmacy Opjs university, churu Rajasthan India
 
Subject Pharmaceutical Sciences; Pharmaceutics; Drug Delivery
lyophilization, indomethacin, Solid dispersions, Dissolution, Stability
 
Description The solid dispersions of indomethacin with hydrophilic polymers were prepared by lyophilization. The polymers used in the investigation were HPMC, PVP K30, CBR and PLF 127. The solubility and dissolution of indomethacin from prepared lyophilized solid dispersions were investigated in 0.1 N HCl, purified water and USP-NF dissolution media.  Out of fifteen lyophilized formulations from F1 to F15, five formulations F2, F5, F8, F12 and F14 showed highest solubility in purified water. Formulation F2, F8 failed to comply with the USP-NF dissolution test for indomethacin capsules. Formulation F14 showed maximum dissolution in the respective dissolution media within 60 min.  Sustained drug release was observed for 6 h with formulations F2 and F8 in USP-NF media. The formulations F2, F5, F8, F12 and F14 were characterized by modulated DSC and FT-IR spectroscopy. Some Formulations on stability testing were found physico-chemically stable at accelerated temperature conditions.
 
Publisher Advanced Research Journals
 
Contributor
 
Date 2017-10-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/2173
10.5138/09750215.2173
 
Source International Journal of Drug Delivery; Vol 9, No 3 (2017): International Journal of Drug Delivery; 71-83
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/2173/pdf
 
Rights Copyright (c) 2017 Rakesh Kumar Sharma, Anil Kumar Middha
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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