Sustained release formulation of metformin-solid dispersion based on gelucire 50/13- PEG4000: an in vitro study

International Journal of Drug Delivery

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Title Sustained release formulation of metformin-solid dispersion based on gelucire 50/13- PEG4000: an in vitro study
 
Creator Momoh, Mumini A; Drug Delivery Research Unit, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences University of Nigeria Nsukka, Enugu State, Nigeria.
Ugwu, Calister E; Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences University of Nigeria Nsukka, Enugu State, Nigeria.
Jackson, Tenderwealth Clement; Department Pharmaceutics and Pharmaceutical Technology, University of Uyo, Akwa-Ibom, Nigeria.
Udodiri, Ngumezi C; Drug Delivery Research Unit, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences University of Nigeria Nsukka, Enugu State, Nigeria.
 
Subject Pharmaceutical Sciences; Pharmaceutics; Drug Delivery
Solid dispersion, Metformin, Gelucire, bioavailability and characterisation
 
Description Metformin is a hydrophilic hypoglycemic agent with permeability and short half-life problems which leads to its low bioavailability. Solid dispersion is one of the unique approaches, to improve bioavailability profiles of drugs. The aim of this study was to prepare and evaluate solid dispersions (SDs) of metformin with polyethylene glycol 4000 (PEG 4000) and Gelucire®50/13 in order to increase its permeability and bioavailability. Solid dispersions of Metformin containing various ratios of PEG 4000: Gelucire®50/13 (1:1, 1:2, 2:1, 1:4, 4:1 as Batch A, Batch B, Batch C, Batch D and Batch E) were prepared using solvent evaporation and fusion techniques. The physical mixtures which served as controls were also prepared. The SDs were evaluated using encapsulation efficiency, percentage yield. The formulations were also characterized with FTIR and DSC. The in vitro drug release studies were also evaluated. The results obtained showed that solid dispersion formulations at pH, 1.2 and 7.4 demonstrated higher release rates than the pure drug. The SDs showed high drug release rates and encapsulation efficiency (% EE) although Batch C containing PEG 4000 and Gelucire 50/13 in the ratio of 2:1 appeared as the batch with most % EE, drug release with broad melting peak. The release rate of metformin increased with increasing amount of PEG 4000. Batch C, SDs containing PEG 4000 and Gelucire 50/13 in the ratio of 2:1 were found to be the most optimized batch with enhanced encapsulation efficiency, most drug release and therefore, improved permeability and bioavailability of metformin.
 
Publisher Advanced Research Journals
 
Contributor
 
Date 2017-10-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/2162
10.5138/09750215.2162
 
Source International Journal of Drug Delivery; Vol 9, No 3 (2017): International Journal of Drug Delivery; 52-70
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/2162/pdf
 
Rights Copyright (c) 2017 Mumini A Momoh, Calister E Ugwu, Tenderwealth Clement Jackson, Ngumezi C Udodiri
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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