A Retrospective Cohort Study of Kawasaki Disease in Hue Central Hospital for 10 Years (2010–2019)

Jurnal Perspektif Pembiayaan dan Pembangunan Daerah

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Title A Retrospective Cohort Study of Kawasaki Disease in Hue Central Hospital for 10 Years (2010–2019)
 
Creator Huu Son, Nguyen
Kiem Hao, Tran
Hoang Anh, Nguyen Thi
 
Subject Kawasaki disease
Gammaglobulin
Complication
 
Description INTRODUCTION: Kawasaki disease (KD) is an acute self-limited systemic vasculitis of unknown etiology which affects mainly children <5 years of age. If the disease is left untreated, it can lead to serious complications such as inflammation of the blood vessels.
AIM: We aim to evaluate the clinical and laboratory findings and response to therapy of KD at Hue Central Hospital.
METHODS: This is a retrospective study of patients with KD at Pediatric Center of Hue Central Hospital between January 2010 and December 2019. Clinical and laboratory examinations as well as the echocardiograms finding were analyzed.
RESULTS: All patients were under 5 years old, in which boys were more than girls. Fever lasting over 5 days, changing in the mouth mucosa, and peripheral extremities were seen in all patients. About 73.2% had bilateral conjunctivitis and 78.0% had rash. About 42.3% of patients had cervical lymphadenopathy. Laboratory findings were noted with 84.5% of patients had hyperleukocytosis (>12,000/ mm3), 76.2% of patients had high serum C-reactive protein (CRP) levels (>100 mg/dl), 56% of patients had erythrocyte sediment rate >60 mm in the 1st h, and 34.5% of patients had thrombocytosis (platelet count >500,000/mm3) at the time of diagnosis. About 26.2% of patients had coronary artery lesions. Most patients (84.4%) had good outcome since the first dose of gamma-globulin and 13% of patients needed the second dose. There was a significant correlation between coronary artery abnormalities and no or late treatment of gamma-globulin.
CONCLUSION: KD was very common in children under 5 years old with the high rate of coronary artery lesion. Treatment with gamma-globulin on or before 10 days of fever resulted in better coronary outcomes and decreased the total length of time of clinical symptoms.
 
Publisher Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia
 
Date 2020-04-10
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://www.id-press.eu/mjms/article/view/3858
10.3889/oamjms.2020.3858
 
Source Open Access Macedonian Journal of Medical Sciences; Vol. 8 No. B (2020): B - Clinical Sciences; 99-103
1857-9655
 
Language eng
 
Relation https://www.id-press.eu/mjms/article/view/3858/4555
 
Rights Copyright (c) 2020 Nguyen Huu Son, Tran Kiem Hao, Nguyen Thi Hoang Anh (Author)
http://creativecommons.org/licenses/by-nc/4.0
 

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