ANTIOXIDANT AND ANTIPROLIFERATIVE ACTIVITIES OF DIFFERENT CULTIVARS OF TOMATOES (LYCOPERSICON ESCULENTUM) ON TUMORAL CELL LINES

JOURNAL OF ADVANCES IN BIOLOGY

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Field Value
 
Title ANTIOXIDANT AND ANTIPROLIFERATIVE ACTIVITIES OF DIFFERENT CULTIVARS OF TOMATOES (LYCOPERSICON ESCULENTUM) ON TUMORAL CELL LINES
 
Creator Tommonaro, Giuseppina
Piscitelli, Concetta
Lavorgna, Margherita
Isidori, Marina
Russo, Chiara
Prisco, Rocco De
Abbamondi, Gennaro Roberto
Iodice, Carmine
 
Description To increase the knowledge about the biological properties of tomatoes, the antioxidant and antiproliferative activities of extracts of nine cultivars of Lycopersicon esculentum, as well as their chemical composition, were studied. The highest antioxidant capacity has been revealed in San Marzano Cirio 3 and Pomodoro Giallo cultivars, both in hydrophilic and lipophilic fractions, while San Marzano, Corbarino di Corbara, and Pomodoro Giallo exhibited the best radical scavenger  activity in methanolic fraction. As regards the antiproliferative activity, the median inhibition concentrations of the lipophilic extracts ranged from 272.3 (Pomodoro Giallo) to 364.4 (Corbarino di Corbara) mg dried extract L-1 on Hep-G2 and from 324.6 (San Marzano Cirio 3) to 455.4 (Nero di Sicilia) on Caco-2. The methanolic extracts were more active on Caco-2 than Hep-G2, while the hydrophilic extracts were not active. These biological properties could be ascribed to the identified  carotenoids and phenolic acids as well as to a pull of minor compounds exerting their synergistic effect.
 
Publisher CIRWORLD
 
Date 2017-08-07
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://cirworld.com/index.php/jab/article/view/6187
10.24297/jab.v10i2.6187
 
Source JOURNAL OF ADVANCES IN BIOLOGY; Vol 10 No 2 (2017); 2061-2072
2347-6893
 
Language eng
 
Relation http://cirworld.com/index.php/jab/article/view/6187/6194
 
Rights Copyright (c) 2017 JOURNAL OF ADVANCES IN BIOLOGY
http://creativecommons.org/licenses/by/4.0
 

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