Endocrine Manifestations in Thalassemia Intermedia

Baru

View Publication Info
 
 
Field Value
 
Title Endocrine Manifestations in Thalassemia Intermedia
 
Creator Khadse, Savita
Sharma, Sujata
Shah, Nikita
 
Description Background: Thalassemia intermedia are genetically similar to thalassemia major with homozygous β-globin chain defect. Transfusion-independence in such patients is not without side effects. The present study was undertaken to determine the prevalence of endocrine complications in patients of thalassemia intermedia.
Methods:  Total 40 patients of thalassemia intermedia were enrolled in the study and divided into 2 groups. Group 1 consist of transfusion dependent (TD) patients (n=24) and group 2 consist of transfusion independent (NTD) patients (n= 16).
Results: Among group 1, commonest endocrine morbidity was short stature (85%), pubertal delay (57.5%), osteopenia (42.5%), osteoporosis (15%), hypothyroidism (15%) and diabetes mellitus (7.5%). While in group 2, short stature (70%), pubertal delay (55%), osteopenia (40%), osteoporosis (22.5%), no case of hypothyroidism and diabetes mellitus. Mean serum ferritin of group 1 was -3562.2 and group 2 was 913.2 and the difference between 2 groups being significant (p=0.0001) indicates that higher iron overload is correlating in group 1 patients having more incidence of endocrine manifestations.
Conclusions: There is significant difference in patients of non-transfusion dependent and transfusion dependent thalassemia intermedia in terms of endocrine manifestations with short stature being the most common manifestation.
 
Publisher Scholar Science Journals
 
Date 2019-09-29
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://ssjournals.com/index.php/ijbar/article/view/5274
10.7439/ijbar.v10i9.5274
 
Source International Journal of Biomedical and Advance Research; Vol 10 No 9 (2019): Sep; e5274
2229-3809
2455-0558
 
Language eng
 
Relation https://ssjournals.com/index.php/ijbar/article/view/5274/3562
 
Rights Copyright (c) 2019 International Journal of Biomedical and Advance Research
http://creativecommons.org/licenses/by/4.0
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library