Endocrine Manifestations in Thalassemia Intermedia


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Title Endocrine Manifestations in Thalassemia Intermedia
Creator Khadse, Savita
Sharma, Sujata
Shah, Nikita
Description Background: Thalassemia intermedia are genetically similar to thalassemia major with homozygous β-globin chain defect. Transfusion-independence in such patients is not without side effects. The present study was undertaken to determine the prevalence of endocrine complications in patients of thalassemia intermedia.
Methods:  Total 40 patients of thalassemia intermedia were enrolled in the study and divided into 2 groups. Group 1 consist of transfusion dependent (TD) patients (n=24) and group 2 consist of transfusion independent (NTD) patients (n= 16).
Results: Among group 1, commonest endocrine morbidity was short stature (85%), pubertal delay (57.5%), osteopenia (42.5%), osteoporosis (15%), hypothyroidism (15%) and diabetes mellitus (7.5%). While in group 2, short stature (70%), pubertal delay (55%), osteopenia (40%), osteoporosis (22.5%), no case of hypothyroidism and diabetes mellitus. Mean serum ferritin of group 1 was -3562.2 and group 2 was 913.2 and the difference between 2 groups being significant (p=0.0001) indicates that higher iron overload is correlating in group 1 patients having more incidence of endocrine manifestations.
Conclusions: There is significant difference in patients of non-transfusion dependent and transfusion dependent thalassemia intermedia in terms of endocrine manifestations with short stature being the most common manifestation.
Publisher Scholar Science Journals
Date 2019-09-29
Type info:eu-repo/semantics/article
Peer-reviewed Article
Format application/pdf
Identifier https://ssjournals.com/index.php/ijbar/article/view/5274
Source International Journal of Biomedical and Advance Research; Vol 10 No 9 (2019): Sep; e5274
Language eng
Relation https://ssjournals.com/index.php/ijbar/article/view/5274/3562
Rights Copyright (c) 2019 International Journal of Biomedical and Advance Research

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