Role of Quercetin in chemoprevention against wide range of carcinogens and mutagens

International Journal of Drug Delivery

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Field Value
 
Title Role of Quercetin in chemoprevention against wide range of carcinogens and mutagens
 
Creator Shivakumar, Savithiri; Palamur Biosciences Private Limited, SVS Medical College Campus, Mahabubnagar-509001, Telangana, India. 2 School of Life Sciences, Manipal University, Manipal 576104, Karnataka, India.
Tadakaluru, Yasodha Lakshmi; Palamur Biosciences Private Limited, SVS Medical College Campus, Mahabubnagar-509001, Telangana, India.
Yakkanti, Raja Ratna Reddy; School of Life Sciences, Manipal University, Manipal 576104, Karnataka, India. Central Research Laboratory, SVS Medical College Campus, Mahabubnagar-509001, Telangana, India.
Suresh, Sannidhi Ranga; Central Research Laboratory, SVS Medical College Campus, Mahabubnagar-509001, Telangana, India.
Sekhar, Pasula Chandra; Manipal university, manipal
 
Subject Pharmaceutical Sciences; Pharmaceutics; Drug Delivery
Pharmaceutical Sciences; Pharmaceutics; Drug Delivery
 
Description Quercetin is a ubiquitous plant flavoniod with significant pharmacological and clinical activity. In this study we determined to demonstrate the protective role of quercetin against range of mutagens and carcinogens in a combination of in vitro and in vivo studies via different mechanisms. Quercetin demonstrated significant protective role against sodium azide, benzo(a)pyrene, cyclophosphamide monohydrate, methyl methane sulphonate and etoposide compared to other mutagens. Quercetin is effective in both in vitro and in vivo test conditions and also in the presence as well as in the absence of metabolic activation system (Rat liver S9).  Auto oxidation, antioxidant properties, inhibition of pro-mutagens metabolism by CYP1A activity and multiple antimutagenic and adaptive response, mechanisms of quercetin may account for its protective role in cancer prevention. In conclusion, the results clearly indicate that quercetin plays a significant role against mutagens that act by direct DNA binding (form DNA adducts), pro-mutagens and alkylating agents with free radical generation; which could be the rationale for its potent anticancer activity against particular cancer types.
 
Publisher Advanced Research Journals
 
Contributor
 
Date 2017-06-21
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/2040
10.5138/09750215.2040
 
Source International Journal of Drug Delivery; Vol 9, No 1 (2017): International Journal of Drug Delivery; 09-17
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/2040/pdf
 
Rights Copyright (c) 2017 Savithiri Shivakumar, Yasodha Lakshmi Tadakaluru, Raja Ratna Reddy Yakkanti, Sannidhi Ranga Suresh, Pasula Chandra Sekhar
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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