Analgesic Activity of Rambutan Seeds Extract (Nephelium lappaceum L.) in White Male Mice

Health Information : Jurnal Penelitian

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Title Analgesic Activity of Rambutan Seeds Extract (Nephelium lappaceum L.) in White Male Mice
Uji Aktivitas Analgetik Ekstrak Biji Rambutan (Nephelium lappaceum L.) terhadap Mencit Putih Jantan
 
Creator Fadilah, Nitya Nurul
Nofriyaldi, Ali
Fatwa, Elsa Nur
 
Subject Extract
Rambutan Seeds
Analgesic
Mice
Ekstrak
Biji rambutan
Analgetik
Mencit
 
Description Indonesia is rich in natural ingredients that have the potential as traditional medicinal plants, one of which is rambutan (Nephelium lappaceum L.) which is empirically efficacious as a pain treatment. The purpose of this study was to determine the analgesic activity of the ethanol extract of rambutan seeds and to determine the optimal dose of rambutan seed extract as an analgesic for white male mice. Rambutan seeds contain several main compounds such as flavonoids, tannins and saponins which are known to have analgesic activity. Rambutan extraction was carried out by maceration method using 70% ethanol, then phytochemical screening tests and extract drying shrinkage were carried out. Analgesic activity testing was carried out as many as 25 male white mice weighing 20-30 grams were divided into 5 groups. The treatment was carried out by administering the preparation between the negative control groups given 1% Na-CMC suspension. The positive control group or the comparison group were given paracetamol 1.3 mg/20 g BW of mice. The test dose group was given various doses of rambutan seed extract 37.5 mg, 75 mg, and 150 mg/20 g BW. Then observed stretching for 60 minutes, obtained the average stretch. The data obtained were analyzed by ANOVA test and LSD further test. The most effective dose is dose II 75 mg/20 g BW of mice. The results of this study are expected to prove that rambutan extract can empirically be useful as an alternative medicine for pain treatment.
Indonesia kaya akan bahan alam yang berpotensi sebagai tanaman obat tradisional, salah satunya tanaman rambutan (Nephelium lappaceum L.) yang secara empiris berkhasiat sebagai pengobatan nyeri. Tujuan penelitian ini untuk mengetahui aktivitas analgetik ekstrak etanol biji rambutan dan untuk mengetahui dosis ekstrak biji rambutan yang paling optimal sebagai analgetik terhadap mencit putih jantan. Biji rambutan mengandung beberapa senyawa utama seperti flavonoid, tanin dan saponin yang diketui mempunyai aktivitas analgetik. Ekstraksi rambutan dilakukan dengan metode maserasi menggunakan etanol 70%, kemudian dilakukan pengujian skrining fitokimia dan susut pengeringan ekstrak. Pengujian aktivitas analgetik dilakukan  sebanyak 25 ekor mencit putih jantan berat 20-30gram dibagi dalam 5 kelompok. Perlakuan dilakukan dengan cara pemberian sediaan antar kelompok kontrol negatif diberikan suspensi Na-CMC 1%. Kelompok kontrol positif atau pembanding diberikan parasetamol 1,3 mg/20 g BB mencit. Kelompok dosis uji diberikan variasi dosis ekstrak biji rambutan 37,5 mg, 75 mg, dan 150 mg/20 g BB. Kemudian diamati geliatnya selama 60 menit, didapat rata-rata geliat. Data yang diperoleh dianalisis dengan uji ANOVA dan uji lanjut LSD. Dosis yang paling efektif yakni dosis II 75 mg/ 20 g BB mencit. Hasil dari penelitian ini diharapkan dapat membuktikan ekstrak rambutan yang secara empiris dapat bermanfaat sebagai obat alternatif untuk pengobatan nyeri.
 
Publisher Poltekkes Kemenkes Kendari
 
Date 2021-12-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-Reviewed Article
Artikel Reviu Komunitas
 
Format application/pdf
 
Identifier http://myjurnal.poltekkes-kdi.ac.id/index.php/HIJP/article/view/382
10.36990/hijp.v13i2.382
 
Source Health Information : Jurnal Penelitian; Vol. 13 No. 2 (2021): Juli-Desember; 128-139
Health Information : Jurnal Penelitian; Vol 13 No 2 (2021): Juli-Desember; 128-139
2622-5905
2085-0840
10.36990/hijp.v13i2
 
Language ind
 
Relation http://myjurnal.poltekkes-kdi.ac.id/index.php/HIJP/article/view/382/315
 
Rights Hak Cipta (c) 2021 Nitya Nurul Fadilah, Ali Nofriyaldi, Elsa Nur Fatwa
https://creativecommons.org/licenses/by-sa/4.0
 

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