Chemical Composition and Cytotoxic Activity of Pistacia atlantica var. kurdica Fruits

ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY

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Title Chemical Composition and Cytotoxic Activity of Pistacia atlantica var. kurdica Fruits
 
Creator A. Kaskoos, Raad
Javed Ahamad
Uthirapathy, Subasini
 
Subject Pistacia atlantica var. kurdica
Anacardiaceae
Cancer
Gas chromatography–mass spectroscopy
A549 cell lines
(3-4,5 dimethylthiazol-2yl2,5-diphenyl tetrazolium bromide) assay
 
Description Pistacia atlantica var. kurdica (Anacardiaceae) is a major subspecies found in the Kurdistan region of Iraq and has several beneficial bioactivities such as antioxidant, antibacterial, and antiviral. P. atlantica growing in the Kurdistan region is not yet studied phytochemically and pharmacologically. Hence, the goal of the present study is to characterize chemical compounds present in ethanolic extract of P. atlantica fruits by gas chromatography–mass spectroscopy (GC–MS) and to evaluate cytotoxic activity using A549 (human lung cancer) cell lines by (3-4,5 dimethylthiazol-2yl2,5-diphenyl tetrazolium bromide) assay. The GC–MS analysis shows the presence of 33 chemical compounds which constitute about 99.95% of total compounds, and isospathulenol (14.63%), spathulenol (13.45%), α-terpineol (13.28%), limonene (10.92%), terpinolene (10.89%), β-myrcene (6.92%), ethyl pentadecanoate (6.15%), β-pinene (4.98%), and caryophyllene oxide (4.01%) were found as major chemical compounds. P. atlantica inhibits cell proliferation in A549 cell lines in a time (24 h) and dose-dependent manner (0.5–500 µg/mL). After 24 h of treatment with P. atlantica, the cell viability of A549 cell lines ranged from 93.01 ± 5.24 to 57.69 ± 4.15% for concentrations of 0.5–500 µg/mL, respectively. This study expands the knowledge of the chemical composition of P. atlantica fruits and provides scientific evidence for its possible use as an anticancer medicine. The substantial anticancer activity of P. atlantica fruits may be due to the presence of isospathulenol, spathulenol, α-terpineol, limonene, terpinolene, β-myrcene, ethyl pentadecanoate, β-pinene, and caryophyllene oxide.
 
Publisher Koya University
 
Date 2021-12-15
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed article
text
 
Format application/pdf
 
Identifier http://aro.koyauniversity.org/index.php/aro/article/view/868
10.14500/aro.10868
 
Source ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY; Vol. 9 No. 2 (2021): Issue Seventeen; 91-95
2307-549X
2410-9355
 
Language eng
 
Relation http://aro.koyauniversity.org/index.php/aro/article/view/868/240
 
Rights Copyright (c) 2021 Raad A. Kaskoos, Javed Ahamad, Subasini Uthirapathy
https://creativecommons.org/licenses/by-nc-sa/4.0
 

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