Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective Activities
ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY
View Publication Info| Field | Value | |
| Title |
Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective Activities
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| Creator |
Uthirapathy, Subasini
Tahir, Tara F. |
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| Subject |
Antioxidants
Cardiac markers Gas chromatography–mass spectrometer Isoproterenol Lipid Triton WR 1339 |
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| Description |
Withania somnifera (WS) (Dunal) or Ashwagandha is a well-known hypolipidemic herb and antioxidant. In this study, 75% ethanolic extract of WS is attempted to evaluate the cardioprotective activity of isoproterenol-induced cardiotoxicity and hypolipidemic activity in Triton WR 1339-induced hyperlipidemia. In addition, phytochemical evaluation of the same extracts analyzed by gas chromatography–mass spectrometer (GC–MS). This study found that 7 days of therapy with WS extracts at 1000 mg/kg b.wt. reduced cholesterol by 76%, low-density lipoprotein (LDL) by 71%, and TAG by 12% (P < 0.05). Furthermore, it can significantly reduce cholesterol and LDL levels (P < 0.05). Similarly, the use of 50 mg/kg b.wt. of WS extract showed a cardioprotective effect against isoproterenol-induced cardiac toxic rats. The antioxidants glutathione, glutathione peroxidase, and catalase are increased in WS extract (P < 0.05), whereas the release of cardiac indicators in heart tissue is reduced (P < 0.05). Furthermore, a 30-day treatment with WS also reduced triacylglycerol in isoprenaline-induced cardiotoxic rats. GC–MS analysis of the methanol fraction of the Ashwagandha 70% ethanolic extract showed the presence of higher concentrations of fatty acids. In conclusion, WS showed hypolipidemic and cardioprotective activities in diseased animals induced by isoproterenol and Triton WR 1339.
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| Publisher |
Koya University
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| Date |
2021-10-15
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion Peer-reviewed article text |
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| Format |
application/pdf
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| Identifier |
http://aro.koyauniversity.org/index.php/aro/article/view/844
10.14500/aro.10844 |
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| Source |
ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY; Vol. 9 No. 2 (2021): Issue Seventeen; 15-21
2307-549X 2410-9355 |
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| Language |
eng
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| Relation |
http://aro.koyauniversity.org/index.php/aro/article/view/844/220
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| Rights |
Copyright (c) 2021 Subasini Uthirapathy, Tara F. Tahir
https://creativecommons.org/licenses/by-nc-sa/4.0 |
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