Fecal Markers of Environmental Enteric Dysfunction and their Relation to Faltering Growth in a Sample of Egyptian Children

Open Access Macedonian Journal of Medical Sciences

View Publication Info
 
 
Field Value
 
Title Fecal Markers of Environmental Enteric Dysfunction and their Relation to Faltering Growth in a Sample of Egyptian Children
 
Creator El Wakeel, Maged A.
El-Kassas, Ghada M.
Fouad Ahmed, Gihan
Ali, Walaa H.
Elsheikh, Eman Mohamed
El-Zayat, Salwa Refat
Fadl, Nevein N.
Kamel, Eman H.
Rabah, Thanaa M.
 
Subject Environmental enteric dysfunction
Undernutrition
Fecal markers
Micronutrients
Children
 
Description BACKGROUND: Chronic malnutrition is a long-term health condition that has threatening effects on children’s health. Environmental enteric dysfunction (EED) is a subclinical disorder affecting the small intestine that may occur due to exposure to environmental pathogens and toxins.


AIM: The present research was intended to detect the value of fecal biomarkers of intestinal epithelial damage alpha-1anti-trypsin (AAT) and intestinal inflammation Myeloperoxidase (MPO) and Neopetrin (NEO), also to quantify their association with faltering growth in stunted and underweight children.


PATIENTS AND METHODS: This case–control study included 105 children with moderate malnutrition as a case group and 100 children of normal body weight and height as a control group. Quantification of fecal markers levels of intestinal permeability AAT and intestinal inflammation (NEO and MPO) along with serum micronutrients levels (iron and zinc) in children with malnutrition in comparison to controls.


RESULTS: Fecal markers of intestinal permeability AAT and intestinal inflammation NEO had statistically significant higher levels in children with malnutrition, while serum micronutrients (iron and zinc) had statistically significant lower levels in children with malnutrition.

CONCLUSION: Faltering growth is associated with elevated fecal markers of intestinal permeability AAT and intestinal inflammation NEO. EED may be a cause for faltering growth.
 
Publisher Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia
 
Date 2021-10-10
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://oamjms.eu/index.php/mjms/article/view/7029
10.3889/oamjms.2021.7029
 
Source Open Access Macedonian Journal of Medical Sciences; Vol. 9 No. B (2021): B - Clinical Sciences; 1117-1122
1857-9655
 
Language eng
 
Relation https://oamjms.eu/index.php/mjms/article/view/7029/6144
 
Rights Copyright (c) 2020 Maged A. El Wakeel, Ghada M. El-Kassas, Gihan Fouad Ahmed, Walaa H. Ali, Eman Mohamed Elsheikh, Salwa Refat El-Zayat, Nevein N. Fadl, Eman H. Kamel, Thanaa M. Rabah (Author)
http://creativecommons.org/licenses/by-nc/4.0
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library