Negative Correlation between Serum Brain-derived Neurotrophic Factor Levels and Obesity Predictor Markers and Inflammation Levels in Females with Obesity

Open Access Macedonian Journal of Medical Sciences

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Field Value
 
Title Negative Correlation between Serum Brain-derived Neurotrophic Factor Levels and Obesity Predictor Markers and Inflammation Levels in Females with Obesity
 
Creator Raharjo, Slamet
Pranoto, Adi
Rejeki, Purwo Sri
Harisman, Ahmad Syahru Mubarok
Pamungkas, Yualita Putri
Andiana, Olivia
 
Subject Obesity
Brain-derived neurotrophic factor
Body mass index
Waist hip ratio
Interleukin-6
Tumor necrosis factor-α
 
Description BACKGROUND: Obesity has been widely associated with structural and functional changes in the brain, whereas inflammation is one of the potential mechanisms involved in these changes.
OBJECTIVE: This study aims to prove the relationship between serum brain-derived neurotrophic factor (BDNF) levels and obesity predictor markers (body mass index and waist to hip ratio) and inflammation (interleukin-6 and Tumor Necrosis Factor-alpha) levels in females with obesity.
METHODS: This study used a cross-sectional study method using 33 females with obesity aged 19-23 years, body mass index (BMI) > 27.5 kg/m2, normal blood pressure, normal resting heart rate (RHR), normal hemoglobin (Hb), and fasting blood glucose (FBG) ≤ 100 mg/dL. The examination of serum BDNF, IL-6, and TNF-α levels using the Enzyme-Linked Immunosorbent Assay (ELISA) method. The data were analyzed using Pearson product-moment test with a significant levels p<0.05.
RESULTS: The results indicated that there is a negative correlation between serum BDNF levels and BMI (r = –0.759; p<0.001), WHR (r = –0.675; p<0.001), IL-6 levels (r = –0.530; p<0.001) and TNF-α levels (r = –0.561; p<0.001).
CONCLUSION: Based on the results of the study, there is a negative correlation between serum BDNF levels and BMI, waist to hip ratio, and inflammation (interleukin-6 and Tumor Necrosis Factor-alpha) levels in females with obesity. Further studies are needed to confirm the present findings.
 
Publisher Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia
 
Date 2021-09-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://oamjms.eu/index.php/mjms/article/view/6840
10.3889/oamjms.2021.6840
 
Source Open Access Macedonian Journal of Medical Sciences; Vol. 9 No. B (2021): B - Clinical Sciences; 1021-1026
1857-9655
 
Language eng
 
Relation https://oamjms.eu/index.php/mjms/article/view/6840/6093
 
Rights Copyright (c) 2020 Slamet Raharjo, Adi Pranoto, Purwo Sri Rejeki, Ahmad Syahru Mubarok Harisman, Yualita Putri Pamungkas, Olivia Andiana (Author)
http://creativecommons.org/licenses/by-nc/4.0
 

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