Antiviral Treatment On Pregnancy With COVID-19 Infection : A Systematic Review

Indonesian Journal of Obstetrics & Gynecology Science

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Field Value
 
Title Antiviral Treatment On Pregnancy With COVID-19 Infection : A Systematic Review
 
Creator Simanjuntak, Tigor Peniel
Kakerissa, Angela Putri
Kurniawan, Grady Ivan
 
Subject Antiviral, pregnant, covid-19
 
Description Objective to evaluate antiviral treatment, duration, and side effects on pregnant women based on gestational age and severity of COVID-19 infection. Method: a systematic review of antiviral treatment, duration, and side effects on pregnant women based on gestational age and severity of COVID-19 infection. Systematic review was conducted following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) Statement.  Result 948 papers accessed through Pubmed, Scopus, Science Direct, Cohcrane, and other with keywords “Antiviral”, “Pregnancy” “Pregnant” “Coronavirus” “COVID-19” “SARS-CoV-2”. Duplicate papers were excluded (n=302),  topics and abstracts that do not meet the criteria (n=612), and 25 papers that did not meet the inclusion criteria. 9 papers that meet the inclusion criteria (case reports and cohort retrospective case study) discussed 20 pregnant women with COVID-19 infection (16 moderate and severe cases received Remdesivir, 3 moderate and mild cases received Lopinavir-ritonavir combination, and 1 moderate case received Arbidol). Conclusion, remdesivir is an antiviral frequently used in pregnancy on trimester II and III with severe COVID-19 infection with a duration of treatment of 5-10 days. Remdesivir should be monitored because some show side effects of increasing liver function.Pengobatan Ibu Hamil yang Terinfeksi  COVID−19 dengan AntivirusAbstrakTujuan untuk mengevaluasi penggunaan obat antivirus, lama pengobatan, dan efek samping pada wanita hamil dengan infeksi COVID-19 berdasarkan usia kehamilan dan derajat keparahan. Metode tinjauan literatur sistematis tentang penggunaan obat antivirus, lama pengobatan, dan efek samping pada wanita hamil dengan infeksi COVID-19 berdasarkan usia kehamilan dan tingkat keparahan. Tinjauan sistematis mengikuti pedoman dari Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Hasil terdapat 948 jurnal yang diakses melalui Pubmed, Scopus, Science Direct, Cohcrane dan lainya dengan kata kunci : Antiviral, Pregnancy, Pregnant, Coronavirus, COVID-19, SARS-CoV-2. Terdapat jurnal yang terduplikasi (n=302), topik dan abstrak yang tidak sesuai kriteria (n=612), dan 25 jurnal yang tidak sesuai kriteria inklusi. Terdapat 9 jurnal yang memenuhi kriteria inklusi (laporan kasus dan studi retrosepktif kohort) yang membahas 20 wanita hamil dengan infeksi COVID-19 (16 kasus dengan derajat sedang dan berat menerima Remdesivir, 3 kasus derajat sedang dan ringan menerima kombinasi Lopinavir-ritonavir, dan 1 kasus derajat sedang menerima Arbidol). Kesimpulan, remdesivir adalah antivirus yang sering digunakan pada wanita hamil trisemester II dan III dengan infeksi COVID-19 derajat berat, lama pengobatan 5-10 hari. Remdesivir harus diwaspadai karena dapat menimbulkan efek samping seperti peningkatan fungsi hati. Kata kunci: Antivirus, Hamil, COVID-19
 
Publisher Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran
 
Contributor none
 
Date 2021-09-29
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.obgynia.com/obgyn/index.php/obgynia/article/view/329
10.24198/obgynia/v4n2s.329
 
Source Obgynia; Special Issue: Article Review; 78-85
Indonesian Journal of Obstetrics & Gynecology Science; Special Issue: Article Review; 78-85
2615-496X
10.24198/obgynia/v4n2s.10
 
Language eng
 
Relation http://www.obgynia.com/obgyn/index.php/obgynia/article/view/329/pdf
http://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/329/192
 
Rights Copyright (c) 2021 Indonesian Journal of Obstetrics & Gynecology Science
 

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