Perbandingan Kadar Antioksi dan Total pada Kanker Serviks Stadium Lanjut Sebelum dan Setelah Kemoterapi

Indonesian Journal of Obstetrics & Gynecology Science

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Title Perbandingan Kadar Antioksi dan Total pada Kanker Serviks Stadium Lanjut Sebelum dan Setelah Kemoterapi
 
Creator Wahidji, Nur Amin
Rauf, Syahrul
Abidin, Nuraini
 
Subject Kadar Antioksidan, Kanker Serviks Stadium Lanjut, Kemoterapi
 
Description Tujuan: Membandingkan kadar antioksidan total pada penderita kanker serviks stadium lanjut sebelum dan setelah kemoterapi.Metode: Merupakan penelitian studi kohort prospektif yang dilakukan di Badan Layanan Umum (BLU) Rumah Sakit Wahidin Sudirohusodo Perawatan onkologi-ginekologi Lontara 4 bawah dan Unit Penelitian Rumah Sakit Perguruan Tinggi Negeri Universitas Hasanuddin. dari perode tanggal 1 Oktober 2019–30 September 2020. Sampel penelitian adalah semua penderita kanker serviks stadium lanjut yang memenuhi kriteria inklusi. Data yang diambil adalah data primer menggunakan questionnaire serta pemeriksaan kadar Anti Oksidan Total dengan metode ELISA. Data yang diperoleh dianalisis dengan menggunakan program komputer SPSS 25.0, Microsoft Excel dan Microsoft Word.Hasil: Terdapat 34 orang sampel penelitian menderita kanker serviks stadium lanjut yang mendapatkan kemoterapi 3 seri. Stadium 2B memiliki perbedaan rerata antioksidan yang signifikan secara statistik. Tipe adenokarsinoma, jenis diferensiasi kategori sedang dan kategori tidak ada keterangan memiliki perbedaan kadar antioksidan yang signifikan secara statistik. Terdapat perbedaan rerata kadar antioksidan total antara sebelum dan sesudah dilakukan kemoterapi dengan p<0,05.Kesimpulan: Terdapat penurunan bermakna kadar antioksidan total sebagai penanda stres oksidatif pada pasien kanker serviks stadium lanjut yang menjalani prosedur kemoterapi.Comparison Total Antioxidant Levels in Patients with Advanced Cervical Cancer Prior and Post-ChemotherapyAbstractPurpose: Comparing total antioxidant levels in patients with advanced cervical cancer prior and post-chemotherapy.Method: This is a prospective cohort study underwent at the Public Service Agency of Wahidin Sudirohusodo Hospital, Lontara 4 Bawah oncology-gynecology care and Research Unit of State University Hospital, Hasanuddin University from October 1st, 2019 to September 30th, 2020. The study sample being used was all patients with advanced cervical cancer who met the inclusion criteria. The data extracted were primary data using a questionnaire, as well as the examination of Total Anti-Oxidant levels using the ELISA method. The data obtained were analyzed further using a computer program SPSS 25.0, Microsoft Excel, and Microsoft Word.Outcome: Approximately 34 study samples were suffering from advanced cervical cancer who undergone 3 series of chemotherapy. Stage 2B revealed a statistically significant difference in antioxidant level. The type of adenocarcinoma, the type of the moderate category differentiation, and the no description category had statistically significant differences in antioxidant levels. It was identified that there was a difference in the mean total antioxidant level between prior and post-chemotherapy with p < 0.05.Conclusion: There was a significant decline in the total antioxidant levels to indicate a sign of oxidative stress in advanced cervical cancer patients who are undergoing chemotherapy procedures.Key word: Antioxidant Levels, Advanced Cervical Cancer, Chemotherapy
 
Publisher Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran
 
Contributor
 
Date 2021-09-29
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Back Matter
 
Format application/pdf
 
Identifier http://www.obgynia.com/obgyn/index.php/obgynia/article/view/285
10.24198/obgynia/v4n2.285
 
Source Obgynia; Volume 4 Nomor 2 September 2021; 134-142
Indonesian Journal of Obstetrics & Gynecology Science; Volume 4 Nomor 2 September 2021; 134-142
2615-496X
10.24198/obgynia/v4n2.9
 
Language eng
 
Relation http://www.obgynia.com/obgyn/index.php/obgynia/article/view/285/pdf
 
Rights Copyright (c) 2021 Indonesian Journal of Obstetrics & Gynecology Science
 

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