Effects of enteral glutamine supplementation on intestinal permeability in acute pancreatitis: A literature review

World Nutrition Journal

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Field Value
 
Title Effects of enteral glutamine supplementation on intestinal permeability in acute pancreatitis: A literature review
 
Creator Setiawan, Evania Astella
Sunardi, Diana
 
Subject glutamine
enteral
acute pancreatitis
intestinal permeability
 
Description Background. Glutamine has been shown to improve the gut mucosal barrier. However, the evidence for benefit of enteral glutamine on intestinal permeability in acute pancreatitis (AP) is limited.
Objective. To identify the effect of enteral glutamine supplementation on intestinal permeability in patients with AP.
Method. A systematic search was conducted by extracting evidence from published studies on enteral glutamine supplementation in three databases (PubMed, Cochrane Central Register of Controlled Trials, and SciElo) relevant to AP from 1 January 2010 till 31 December 2020. Outcomes assessed were intestinal permeability, infectious complication, hospital length of stay, and mortality rate.
Results. A total of 6 studies found by search, in which 2 human RCTs with 7 days duration of intervention with 1b-1c quality based on Criteria by Center of Evidence-Based Medicine, University of Oxford. Both studies showed the benefit of early enteral glutamine supplementation on intestinal permeability in patients with AP.
Conclusions. Enteral glutamine supplementation has been shown to improve the gut mucosal barrier in AP. Despite its significant improvement in intestinal permeability, glutamine supplementation did not display a consistently positive effect on clinical outcomes.
 
Publisher Indonesian Nutrition Association
 
Date 2021-08-27
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://worldnutrijournal.org/OJS/index.php/WNJ/article/view/WNJ.V04.i2.0007
10.25220/WNJ.V04.i2.0007
 
Source World Nutrition Journal; Vol. 4 No. 2 (2021): Volume 04 Issue 2 August 2021; 46-56
2580-7013
 
Language eng
 
Relation https://worldnutrijournal.org/OJS/index.php/WNJ/article/view/WNJ.V04.i2.0007/215
 
Rights Copyright (c) 2021 Evania Astella Setiawan, Diana Sunardi
https://creativecommons.org/licenses/by-nc-sa/4.0
 

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