Effects of Vitamin D and Simvastatin on Inflammatory and Oxidative Stress Markers of High-Fat Diet-Induced Obese Rats

Journal of Scientific Research in Medical and Biological Sciences

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Title Effects of Vitamin D and Simvastatin on Inflammatory and Oxidative Stress Markers of High-Fat Diet-Induced Obese Rats
 
Creator Makhlouf, Abdel-Moniem A.
Mahmoud, Atef M.
Ibrahim, Rania G.
Abdel Aziz, Yasmeen S.
 
Subject Simvastatin, Vitamin D, HFD, Oxidative stress, Inflammation
 
Description Purpose: This study was aimed to evaluate the antioxidant and anti-inflammatory effects of vitamin D and Simvastatin (SIM) on a high-fat diet (HFD) induced-obese rats.
Methods: 40 adult male rats were divided into four groups: control group, HFD, HFD + vitamin D, and HFD + SIM for 14 weeks. Vitamin D or SIM supplementation was done for the last 6 weeks. Vitamin D dosage was 500 IU/kg, while SIM dosage was 10 mg/kg. Interleukin-6 (IL-6) concentration and markers of oxidative stress including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), and reduced glutathione(GSH) concentrations in serum were determined using ELISA kits and spectrophotometry methods, respectively.
Results: Treatment with vitamin D or SIM could significantly reduce IL-6 and MDA and increases SOD, GPx activities, and GSH levels. Oxidative stress can result not only from increased ROS production but also from dysfunctional antioxidant defenses.
Conclusion: From the experimental results, it was observed that SIM and vitamin D could attenuate oxidative stress and inflammation markers associated with obesity.
 
Publisher Baynoon Centre for Studies and Development (BCSD)
 
Date 2021-08-12
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://bcsdjournals.com/index.php/jsrmbs/article/view/297
10.47631/jsrmbs.v2i3.297
 
Source Journal of Scientific Research in Medical and Biological Sciences; Vol. 2 No. 3 (2021): Journal of Scientific Research in Medical and Biological Sciences; 39-50
2709-1511
2709-0159
 
Language eng
 
Relation http://bcsdjournals.com/index.php/jsrmbs/article/view/297/166
 
Rights Copyright (c) 2021 Journal of Scientific Research in Medical and Biological Sciences
https://creativecommons.org/licenses/by/4.0
 

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