Polymyxins: “Last Resort” for MDR and/or XDR Gram-Negative Infections
Journal of Scientific Research in Medical and Biological Sciences
View Publication Info| Field | Value | |
| Title |
Polymyxins: “Last Resort” for MDR and/or XDR Gram-Negative Infections
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| Creator |
Ahmed, Manal Mohamed Elsayed
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| Subject |
polymyxins, polymyxin B, colistin, MDR Gram-negative infections, XDR Gram-negative infections, antimicrobial drug resistance, Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, combination therapy.
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| Description |
Polymyxins were used for the management of gram-negative infections in clinical practice science1940s. Parenteral administration waned in the seventies owing to polymyxins nephrotoxicity and neurotoxicity. Because of the lack of treatment choices for MDR and/or XDRgram negative superbugs as well as Acinetobacter baumannii, Klebsiella pneumonia, and Pseudomonas aeruginosa, there is a growing need for effective prescribing of old antibiotics that are still effective. However, understanding of polymyxins pharmacokinetics (PK) was restricted and clinical experience is limited which leads to a lack of widespread availability of up-to-date dosing guidelines that could potentially result in the incorrect use of these “last resort” antibiotics. Recently, polymyxin B resistant strains are also a reason of concern. In this review, we discuss the importance of preserving the effectiveness of polymyxins for nosocomial gram-negative infections and strategies to improve polymyxins’ prescription. We recommend that polymyxins should only be used to manage significant MDR and/or XDRgram-negative infections, in optimum doses and if possible, in combination therapy
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| Publisher |
Baynoon Centre for Studies and Development (BCSD)
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| Date |
2021-08-12
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion |
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| Format |
application/pdf
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| Identifier |
http://bcsdjournals.com/index.php/jsrmbs/article/view/242
10.47631/jsrmbs.v2i3.242 |
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| Source |
Journal of Scientific Research in Medical and Biological Sciences; Vol. 2 No. 3 (2021): Journal of Scientific Research in Medical and Biological Sciences; 104-122
2709-1511 2709-0159 |
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| Language |
eng
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| Relation |
http://bcsdjournals.com/index.php/jsrmbs/article/view/242/170
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| Rights |
Copyright (c) 2021 Journal of Scientific Research in Medical and Biological Sciences
https://creativecommons.org/licenses/by/4.0 |
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