Polymyxins: “Last Resort” for MDR and/or XDR Gram-Negative Infections

Journal of Scientific Research in Medical and Biological Sciences

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Title Polymyxins: “Last Resort” for MDR and/or XDR Gram-Negative Infections
 
Creator Ahmed, Manal Mohamed Elsayed
 
Subject polymyxins, polymyxin B, colistin, MDR Gram-negative infections, XDR Gram-negative infections, antimicrobial drug resistance, Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, combination therapy.
 
Description Polymyxins were used for the management of gram-negative infections in clinical practice science1940s. Parenteral administration waned in the seventies owing to polymyxins nephrotoxicity and neurotoxicity. Because of the lack of treatment choices for MDR and/or XDRgram negative superbugs as well as Acinetobacter baumannii, Klebsiella pneumonia, and Pseudomonas aeruginosa, there is a growing need for effective prescribing of old antibiotics that are still effective. However, understanding of polymyxins pharmacokinetics (PK) was restricted and clinical experience is limited which leads to a lack of widespread availability of up-to-date dosing guidelines that could potentially result in the incorrect use of these “last resort” antibiotics. Recently, polymyxin B resistant strains are also a reason of concern. In this review, we discuss the importance of preserving the effectiveness of polymyxins for nosocomial gram-negative infections and strategies to improve polymyxins’ prescription. We recommend that polymyxins should only be used to manage significant MDR and/or XDRgram-negative infections, in optimum doses and if possible, in combination therapy
 
Publisher Baynoon Centre for Studies and Development (BCSD)
 
Date 2021-08-12
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier http://bcsdjournals.com/index.php/jsrmbs/article/view/242
10.47631/jsrmbs.v2i3.242
 
Source Journal of Scientific Research in Medical and Biological Sciences; Vol. 2 No. 3 (2021): Journal of Scientific Research in Medical and Biological Sciences; 104-122
2709-1511
2709-0159
 
Language eng
 
Relation http://bcsdjournals.com/index.php/jsrmbs/article/view/242/170
 
Rights Copyright (c) 2021 Journal of Scientific Research in Medical and Biological Sciences
https://creativecommons.org/licenses/by/4.0
 

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