Proliferative Activity of Myoepithelial Cells in of Mucoepidermoid Carcinoma

Open Access Macedonian Journal of Medical Sciences

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Title Proliferative Activity of Myoepithelial Cells in of Mucoepidermoid Carcinoma
Creator Alali, Faisal Mehsen
Tarakji, Bassel
Alqhtani, Nasser Raqe
Nabhan, Abdullah Bin
Alrafedah, Ali
Alenzi, Adel
Kochaji, Nabil
Subject Myoepithelial cells
Mucoepidermoid Carcinoma
Double immunohistochemical labeling
Description AIM: The aim of the study is to investigate the role of myoepithelial cells in the pathogenesis of mucoepidermoid carcinoma (MEC) using the double immunohistochemical staining; α _smooth muscle actin (_α-SMA)as specific marker for the myoepithelial cell differentiation and proliferative cell nuclear antigen (PCNA) as a marker for proliferative activity of myoepithelial cells.

MATERIAL AND METHODS: Retrospective study of twenty salivary gland specimens (ten MEC and ten normal salivary glands) were studied using double immunohistochemical labeling for α _smooth muscle actin α-SMA) and proliferative cell nuclear antigen (PCNA). The SPSS statistical package was used for data analysis (IBM SPSS Statistics for Windows, Version 20.0, Released 2011, IBM Corp, and Armonk, NY, USA).

RESULTS: In mucoepidermoid carcinomas, no positivity of α-SMA was seen in neoplastic cells (Frequent test), and it was just observed in the stroma of tumor, in the walls of blood vessels whereas, PCNA was positive, especially in high-grade tumors. In contrast, in normal salivary glands, the proliferating myoepithelial cells are stained by both α-SMA and PCNA.

CONCLUSIONS: We believe that the myoepithelial cells have no a role in the development of mucoepidermoid carcinoma.
Publisher Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia
Date 2021-07-02
Type info:eu-repo/semantics/article
Format application/pdf
Source Open Access Macedonian Journal of Medical Sciences; Vol. 9 No. A (2021): A - Basic Sciences; 451-454
Language eng
Rights Copyright (c) 2021 Faisal Mehsen Alali, Bassel Tarakji, Nasser Raqe Alqhtani, Abdullah Bin Nabhan, Ali Alrafedah, Adel Alenzi, Nabil Kochaji (Author)

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