Differentiation in Neurological Soft Sign Scores on Schizophrenic Patients with Antipsychotic Treatment

Open Access Macedonian Journal of Medical Sciences

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Field Value
 
Title Differentiation in Neurological Soft Sign Scores on Schizophrenic Patients with Antipsychotic Treatment
 
Creator Thioritz, Wempy
Limoa, Erlyn
Hutomo, J. C.
Syamsuddin, Saidah
Lisal, Sonny T.
 
Subject Haloperidol
Risperidone
Schizophrenia
Neurological soft sign
 
Description Background: Schizophrenia is a chronic mental illness that affects cognitive aspect of a patient which need long term care with antipsychotics. Long term use of antipsychotic itself causes neurobiological change in the brain which results in alteration of cognitive function. The latest research had demonstrated that NSS (Neurological Soft Sign) reflect a rather wide range of cognitive impairments in schizophrenia which was not accounted for by age, education or severity of global cognitive deficits. Therefore, we examined the effects and impact of antipsychotic Haloperidol and Risperidone treatment in schizophrenic patient using NSS scores.
The Study showed that chronic schizophrenia patients had a higher NSS scores than acute patients. NSS also significantly associated with all neuropsychological domains of MMSE in both groups and were confirmed when age, education and severity of global cognitive deficits were not accounted for. This study also obtained a lower NSS score in patients who received Risperidone therapy compared to Haloperidol with p = 0.003. Out of 5 NSS domain in the Heidelberg scale, there was a significant improvement in motor coordination and motor sequencing (p = 0.004) and (p = 0.048) in patients who received Risperidone therapy compared to Haloperidol. There was an association between the chronicity of the disease and NSS, NSS also shows that it’s not influenced by age, education and severity of global cognitive deficits as a screening instrument. Finally the improvement of NSS scores in the Risperidone group was far superior compared to the Haloperidol group particularly in motor coordination and motor sequencing.
 
Publisher Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia
 
Date 2021-07-02
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://oamjms.eu/index.php/mjms/article/view/6356
10.3889/oamjms.2021.6356
 
Source Open Access Macedonian Journal of Medical Sciences; Vol. 9 No. T3 (2021): T3 - Thematic Issue "Neuroscience, Neurology, Psychiatry and General Medicine" ; 249-253
1857-9655
 
Language eng
 
Relation https://oamjms.eu/index.php/mjms/article/view/6356/5790
 
Rights Copyright (c) 2021 Wempy Thioritz, Erlyn Limoa, J. C. Hutomo, Saidah Syamsuddin, Sonny T. Lisal (Author)
http://creativecommons.org/licenses/by-nc/4.0
 

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