The role of family history as a risk factor for non-syndromic cleft lip and/or palate with multifactorial inheritance

Dental Journal (Majalah Kedokteran Gigi)

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Title The role of family history as a risk factor for non-syndromic cleft lip and/or palate with multifactorial inheritance
Creator Sosiawan, Agung
Kurniati, Mala
Danudiningrat, Coen Pramono
Wahjuningrum, Dian Agustin
Mulyawan, Indra
Subject cleft lip with or without cleft palate (CL/P); family history; multifactorial; recurrence
Description Background: Cleft lip with or without cleft palate (CL/P) is a facial growth ‘disorder that occurs during gestation and has multifactorial causes owing to both genetic and environmental factors. Several factors can increase the likelihood of CL/P, and one of them is family history. Differences in results obtained from studies conducted across several countries concerning family history as a risk factor for CL/P suggest there is no consensus on how the condition is inherited. Purpose: This study aims to review the literature on the role of family history as a risk factor contributing to the incidence of non-syndromic CL/P (NSCL/P). Review: This review discusses the etiology of CL/P and the risk factors influencing the incidence of CL/P. The review also examines the criteria for inheriting multifactorial disorders to calculate the risks involved should there be a recurrence of the condition based on family history. Conclusion: CL/P is a type of multifactorial disorder with unclear etiology. Therefore, it is important to investigate the risk factors stemming from family history (which play an important role) related to the recurrence risk. Additionally, there should be focus on increasing genetic education and offering counselling to parents and pregnant women.
Publisher Faculty of Dental Medicine, Universitas Airlangga
Contributor the directorate of Research and Community Services, the deputy director of Research and Development Reinforcement
and the National Research and Innovation Agency of the Republic of Indonesia
Date 2021-06-30
Type info:eu-repo/semantics/article

Format application/pdf
Source Dental Journal (Majalah Kedokteran Gigi); Vol 54, No 2 (2021): June 2021; 108-112
Language eng
Rights Copyright (c) 2021 Dental Journal (Majalah Kedokteran Gigi)

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