Uric Acid and P-Wave Dispersion in Subjects with Heart Failure

Medical Laboratory Technology Journal

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Field Value
 
Title Uric Acid and P-Wave Dispersion in Subjects with Heart Failure
 
Creator Kurt, Recep
Şahin, Anıl
 
Subject cardiology
P-wave dispersion; uric acid; heart failure
 
Description Uric acid used as a marker of cardiovascular risk, which is associated with oxidative stress and inflammation. P-wave dispersion (PWD) is an electrocardiographic measure, which shows heterogeneity of atrial depolarization. It has demonstrated that there is an association of increased PWD with atrial fibrillation. This article's goal was to investigate the relationship between PWD and uric acid in subjects with heart failure (HF). Methods This descriptive, cross-sectional study included a total of 315 stable HF outpatients. The subjects were classified into two groups by their PWD: the normal PWD group consisted of subjects with a PWD lower than 40 ms (n = 201), and the increased PWD group consisted of subjects with a PWD higher than or equal to 40 ms (increased PWD) (n = 114). Results Significantly higher uric acid levels determined in the increased PWD group, in comparison with the normal PWD group (7.4 ± 1.6 mg/dL, vs. 6.5 ± 1.6 mg/dL p < 0.001). Univariate analyses revealed an association between uric acid, blood urea nitrogen, systolic pulmonary artery pressure, left atrial diameter, and increased PWD. In multivariate logistic regression analysis, there was an association of uric acid level (OR: 1.293; 95% CI: 1.106-1.511, p: 0.001), systolic pulmonary artery pressure (OR: 1.027; 95% CI: 1.011-1.044, p: 0.001), and left atrial diameter (OR: 1.754; 95% CI: 1.028-2.992, p: 0.039) with PWD. The receiver operating characteristics (ROC) curve analysis demonstrated that the optimal cut-off level of uric acid for predicting increased PWD was ≥ 7.1 mg/dL with a specificity of 77 percent and a sensitivity of 81 percent. Conclusion Our study results suggest that serum uric acid levels independently correlated with PWD in subjects with HF.
 
Publisher Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan
 
Contributor
 
Date 2021-06-18
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article

 
Format application/pdf
 
Identifier http://www.ejurnal-analiskesehatan.web.id/index.php/JAK/article/view/259
10.31964/mltj.v7i1.259
 
Source Medical Laboratory Technology Journal; Vol 7, No 1 (2021): June; 26-35
2461-0879
10.31964/mltj.v7i1
 
Language eng
 
Relation http://www.ejurnal-analiskesehatan.web.id/index.php/JAK/article/view/259/167
http://www.ejurnal-analiskesehatan.web.id/index.php/JAK/article/downloadSuppFile/259/49
http://www.ejurnal-analiskesehatan.web.id/index.php/JAK/article/downloadSuppFile/259/50
http://www.ejurnal-analiskesehatan.web.id/index.php/JAK/article/downloadSuppFile/259/51
http://www.ejurnal-analiskesehatan.web.id/index.php/JAK/article/downloadSuppFile/259/56
http://www.ejurnal-analiskesehatan.web.id/index.php/JAK/article/downloadSuppFile/259/71
10.31964/mltj.v7i1.259.g167
 
Rights Copyright (c) 2021 RECEP KURT
http://creativecommons.org/licenses/by-nc-sa/4.0
 

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