The role of immunotherapy in eliminating high-risk treatments for pediatric cancer

Journal of Current Biomedical Reports

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Field Value
Title The role of immunotherapy in eliminating high-risk treatments for pediatric cancer
Creator Farhoud, Zahra
Bozorgchenani, Sepehr
Subject Immunology
Children cancer; Natural killer cells; CAR-T
Description Chemotherapy, radiation, and surgery are often ineffective in treating refractory or chronic tumors in children. Recent advances in cancer immunotherapy have also improved the outcome of many human tumors, resulting in significant responses in patients who have previously refused to respond to other treatments. The immune system is made up of cells and proteins that work together to maintain immunity against pathogens. Cancer cells can adapt and metastasize over time, express different neoantigens, or express more immune-suppressing mechanisms, allowing them to be identified and eradicated. In this study, we focus on immunotherapy for pediatric cancer and its progression using natural killer (NK) cells, chimeric antigen receptor T cells (CAR-T), and oncolytic virus cells in these patients. For all intents and purposes, toxicity is a concern. Although immunotherapy is believed to have fewer long-term side effects than chemotherapy and radiation therapy, they may have a high rate of short-term side effects, depending on the cause and purpose. These complications can lead to life-threatening illnesses, from mild illnesses such as fever and headaches to more severe illnesses such as autoimmune, neurotoxicity, and opportunistic infections. Any of the problems listed, for example, cytokine release syndrome, can be fatal. Different intensities require multiple tests and trials.
Publisher ParsPublisher
Date 2021-06-19
Type info:eu-repo/semantics/article

Format application/pdf
Source Journal of Current Biomedical Reports; Vol 2, No 2 (2021). April-June; 51-55
Language eng
Rights Copyright (c) 2021 © The Author(s)

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