The antifungal susceptibility of Candida albicans isolated from HIV/AIDS patients

Dental Journal (Majalah Kedokteran Gigi)

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Title The antifungal susceptibility of Candida albicans isolated from HIV/AIDS patients
Creator Rezeki, Sri
Pradono, Siti Aliyah
Subita, Gus Permana
Rosana, Yeva
Sunnati, S.
Gani, Basri A.
Subject antifungal; Candida albicans; HIV/AIDS; susceptibility and resistance
Description Background: Candida albicans was found to be dominant in patients with human immunodeficiency virus / acquired immunodeficiency syndrome (HIV/AIDS). The antifungals fluconazole, ketoconazole, and nystatin were used as oral candidiasis therapy for HIV/AIDS, each of which has differing susceptibility in oral candidiasis therapy. Purpose: The present study aimed to evaluate the susceptibility and antifungal resistance to oral C. albicans in HIV/AIDS patients. Methods: The subjects followed the universal precaution principles. Oral Candida species were isolated from the saliva of 98 HIV/AIDS subjects. Identification of Candida species was carried out by the mycobiotic agar of API 20 C Aux system. Susceptibility and resistance antifungal tests on the Candida species were performed using a Fungus ATB Kit. Results: Candida albicans was the most dominant species found from 98 subjects (95%). The rest were other Candida species. There are 41 subjects (42%) with a history of oral candidiasis, and 57 subjects (58%) without. The history of those who used antifungals were: nystatin = 60 subjects (61%), fluconazole = 39 subjects (40%), and ketoconazole = two subjects (2%). These antifungals have a susceptibility above 80% against C. albicans, except the nystatin group (79%) (p>0.05; 0.628), but fluconazole has a strong correlation (r=0.820) to susceptibility, susceptibility-dependent dose, and resistance. Conclusion: Candida albicans was dominant in the saliva of HIV/AIDS patients. This fungus was effectively treated by fluconazole, ketoconazole and nystatin. These antifungals had a high susceptibility at ≤ 8 μg/mL to C. albicans.
Publisher Faculty of Dental Medicine, Universitas Airlangga
Date 2021-06-03
Type info:eu-repo/semantics/article

Format application/pdf
Source Dental Journal (Majalah Kedokteran Gigi); Vol 54, No 2 (2021): June 2021; 82-86
Language eng
Rights Copyright (c) 2021 Dental Journal (Majalah Kedokteran Gigi)

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