Estimation of Vitamin D Level in Patients of Chronic Liver Disease and its Association with Child Turcotte Pugh’s Score

Academia Journal of Medicine

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Title Estimation of Vitamin D Level in Patients of Chronic Liver Disease and its Association with Child Turcotte Pugh’s Score
Creator Mavi, Kamal
Kumar, Ajay
Singh, V.K.
Krishna, Hare
Subject Vitamin D
Chronic Liver Disease
Child Turcotte Pugh’s Score
Description Background: Chronic liver disease (CLD) has a fairly high occurrence in the Indian subcontinent due to variety of etiological factors including alcohol abuse, viral hepatitis, etc. As liver plays a crucial role in digestive as well as metabolic functions, its significant dysfunction is related to severe imbalance of vitamin D. Though for long the role of vitamin D in bone mineral metabolism is known yet recent literature has suggested its significant role in immune modulation, inflammatory response and in fibrosis. Since insufficient data on vitamin D levels in CLD patients exists in Indian population, hence we planned this study. Subjects and Methods: Hundred patients of CLD were included in our study following approval from institutional ethics committee, obtaining informed written consent and excluding bone disease, chronic renal disease, known cardiac disease & known malignancy. All patients underwent estimation of vitamin D levels and appropriate tests to diagnose CLD with further categorization into A, B, C as per Child-Turcot-Pugh (CP) Criteria. Appropriate statistical tests were then applied to find out the association between CLD and vitamin D levels. Results: Majority of the CLD patients were males and in 3rd-5th decade with most of them i.e. 89% in our study, had insufficiency or deficiency of vitamin D in their serum with majority having moderate to severe grades of CLD as per CP score. This association was statistically significant with p value of less than <0.01. Also, a negative Pearson correlation was observed meaning thereby that as the CP score increases, the vitamin D levels decrease. Conclusion: Since vitamin D plays a key role in immune based responses, its serum level is crucial in patients suffering with chronic liver diseases, where the serum vitamin D levels decrease as the Child-Turcot-Pugh score of liver disease increases. Early recognition of insufficient or deficient levels of serum vitamin D by their simple & inexpensive serum estimation may go a long way in not only instituting early therapy but also in preventing related morbidities.
Publisher Dr Sanket Hiware, College of Medicine and Health Science, DireDawa University, Ethiopia.
Date 2021-05-10
Type info:eu-repo/semantics/article
Peer-reviewed Article
Format application/pdf
Source Academia Journal of Medicine; Vol 4 No 1 (2021): January-June 2021; 21-26
Language eng
Rights Copyright (c) 2021 Author

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