Formulation And In Vitro/In Vivo Evaluation Of Olmesartan Medoxomil Solid Dispersions Incorporated E/R Trilayer Matrix Tablets By Geomatrix

International Journal of Drug Delivery

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Title Formulation And In Vitro/In Vivo Evaluation Of Olmesartan Medoxomil Solid Dispersions Incorporated E/R Trilayer Matrix Tablets By Geomatrix
 
Creator Balakrishnaiah, M; 1Acharya Nagarjuna University, Nagarjuna nagar, Guntur-522 510, A.P, India. 2Pulla Reddy Institute of Pharmacy, Narsapur road, Medak-502 313, TS, India.
Gupta, V. Rama Mohan; Pulla Reddy Institute of Pharmacy, Narsapur road, Medak-502 313, TS, India.
 
Subject Pharmaceutical Sciences; Pharmaceutics; Drug Delivery
Olmesartan medoxomil, Trilayer matrix tablet, Guar gum, Geomatrix, In-vivo bioavailability studies
 
Description An attempt has been made to develop and optimize an novel anti hypertensive trilayered controlled release matrix tablets incorporated with Olmesartan medoxomil solid dispersion prepared by direct compression and consisted of middle active layer with different grades of hydroxypropylmethylcellulose (HPMC), guar gum, ethyl cellulose. Upper and lower layers are prepared with Carnauba wax, guar gum and sodium CMC. The developed drug delivery system provided prolonged drug release rates over a period of 24 h. The release profile of the optimized formulation (HF14) was described by the Zero-order and Higuchi model. In-vivo bioavailability studies were carried out with the optimized formulation (HF14) and reference standard A fair correlation between the dissolution profile and bioavailability for the optimized formulation was observed. The results indicate that the approach used could lead to a successful development of a trilayer extended release formulation up to 24h. These results also demonstrated that the Olmesartan solid dispersion incorporated trilayer tablets shown more bioavailability because of its conversion from crystalline to amorphous form.
 
Publisher Advanced Research Journals
 
Contributor
 
Date 2017-02-28
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/1948
10.5138/09750215.1948
 
Source International Journal of Drug Delivery; Vol 8, No 4 (2016): International Journal of Drug Delivery; 125-133
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/1948/pdf
 
Rights Copyright (c) 2016 M. Balakrishnaiah, V. Rama Mohan Gupta
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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