Andrographolide Pretreatment Enhances the Bioavailability and Hypoglycemic Action of Glimepiride and Metformin

International Journal of Phytomedicine

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Field Value
 
Title Andrographolide Pretreatment Enhances the Bioavailability and Hypoglycemic Action of Glimepiride and Metformin
 
Creator Samala, Sujatha; University college of Pharmaceutical Sciences,Kakatiya University, Warangal TS 506009
Veeresham, Ciddi; University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana State - 506009, India
 
Subject Glimepiride; Metformin; Andrographolide; Pharmacokinetics; Pharmacodynamics
 
Description Herbal antidiabetic preparations are often used as an add-on therapy in diabetes. Hence, in the present investigation the effect of andrographolide (AD) on the pharmacokinetics and pharmacodynamics of glimepiride and metformin in normal as well as in STZ - induced diabetic rats was studied. In normal and diabetic rats the combination of glimepiride and metformin with AD increased significantly (p < 0.01) all the pharmacokinetic parameters, such as Cmax, AUC0 to n, AUCtotal, t½, MRT and decreased the clearance, Vd markedly as compared with the control group. In pharmacodynamic studies, the combination of glimepiride and metformin with AD provided significant protection against the diabetes induced alterations in the biochemical parameters. In addition, the combination of glimepiride and metformin with AD also improved the total antioxidant status and decreased lipid peroxide levels significantly in diabetic rats compared with AD, glimepiride and metformin alone treated groups. The results revealed that combination of glimepiride and metformin with AD led to the enhancement of the bioavailability of glimepiride and metformin by inhibiting the CYP450 enzymes. In conclusion, add-on preparations containing AD may increase the bioavailability of glimepiride and metformin, which suggested that AD might be beneficial as an adjuvant to glimepiride and metformin in a proper dose, in diabetic patients and hence the doses should be monitored.
 
Publisher AR Journals
 
Contributor
 
Date 2015-10-26
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijpm/article/view/1657
 
Source International Journal of Phytomedicine; Vol 7, No 3 (2015): International Journal of phytomedicine; 254-264
0975-0185
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijpm/article/view/1657/886
http://www.arjournals.org/index.php/ijpm/article/downloadSuppFile/1657/580
 
Rights Copyright (c) 2015 Ciddi Veeresham
http://creativecommons.org/licenses/by/4.0/
 

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