EKSPRESI Hsa-miR-22-3p PADA URIN PASIEN BENIGN PROSTATE HYPERPLASIA (BPH) SEBAGAI BIOMARKER NON INVASIF

Berita Biologi

View Publication Info
 
 
Field Value
 
Title EKSPRESI Hsa-miR-22-3p PADA URIN PASIEN BENIGN PROSTATE HYPERPLASIA (BPH) SEBAGAI BIOMARKER NON INVASIF
 
Creator Prasetyo, Angga Dwi
 
Subject BPH, PSA, TURP, MicroRNA, qRT-PCR, Hsa-miR-22-3p
 
Description Benign Prostate Hyperplasia (BPH) is one of prostate diseases with highest prevalence rates men in the world. Benign Prostate Hyperplasia are caused by many factors, such as disorders of androgen receptors, mutations genes, age, epigenetics and environment. Detection BPH in the form of Prostate Specific Antigen (PSA), Transurethral Resection Of Prostate (TURP) and Digital Rectal Examination (DRE) which is invasive in the patient. MicroRNAs in urine eksosomes can be used to detect BPH with non-invasive to patients. This study aims to determine the potential expression of Hsa-miR-22-3p in eksosomal urine samples of BPH as a non-invasive biomarker. This was an observational cross sectional analytic study. Urine samples were obtained from dr. Sardjito Yogyakarta and dr. Soeradji Tirtonegoro hospital. Furthermore, eksosomes isolation, RNA isolation, cDNA synthesis and quantification with qRT-PCR. Based on the results, it is known that Hsa-miR-22-3p decreased expression as much as 29.54 times in BPH, there were significant differences between samples of BPH and normal samples (P = 0.001). Thus Hsa-miR-22-3p has potential as a biomarker in Benign Prostate Hyperplasia. 
 
Publisher Research Center for Biology-Indonesian Institute of Sciences
 
Contributor
 
Date 2021-05-10
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://e-journal.biologi.lipi.go.id/index.php/berita_biologi/article/view/3990
10.14203/beritabiologi.v20i1.3990
 
Source BERITA BIOLOGI; Vol 20, No 1 (2021); 93-102
BERITA BIOLOGI; Vol 20, No 1 (2021); 93-102
2337-8751
0126-1754
 
Language eng
 
Relation http://e-journal.biologi.lipi.go.id/index.php/berita_biologi/article/view/3990/pdf
http://e-journal.biologi.lipi.go.id/index.php/berita_biologi/article/downloadSuppFile/3990/385
http://e-journal.biologi.lipi.go.id/index.php/berita_biologi/article/downloadSuppFile/3990/386
http://e-journal.biologi.lipi.go.id/index.php/berita_biologi/article/downloadSuppFile/3990/387
http://e-journal.biologi.lipi.go.id/index.php/berita_biologi/article/downloadSuppFile/3990/388
 
Rights Copyright (c) 2021 BERITA BIOLOGI
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library