In Vitro - In Vivo Evaluation Of E/R Trilayer Matrix Tablets Containing Solid Dispersion Of Atorvastatin

International Journal of Drug Delivery

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Field Value
 
Title In Vitro - In Vivo Evaluation Of E/R Trilayer Matrix Tablets Containing Solid Dispersion Of Atorvastatin
 
Creator Thirupathaiah, A; Osmania University Hyderabad
Sunder, R Shyam; Osmania University Hyderabad
 
Subject Pharmaceutical Sciences; Pharmaceutics; Drug Delivery
Atorvastatin, Carbopol 934P, Geomatrix, Trilayer matrix tablet, In-vivo bioavailability studies
 
Description Investigation of in vitro/in vivo behaviour of extended release tablets containing solid dispersions of Atorvastatin is the focus of the present research work. Atorvastatin trilayer matrix tablets were prepared by direct compression method and consisted of middle active layer with different grades of hydroxypropylmethylcellulose (HPMC), ethyl cellulose and Carbopol 934P. Barrier layers are prepared with hydrophobic polymers carnauba wax and xanthan gum. Based on the evaluation parameters, drug dissolution profile and release order kinetics HF16 was found to be optimized formulation. The developed drug delivery system provided prolonged drug release rates over a period of 24 h. The release profile of the optimized formulation (HF16) was described by the Zero-order and best fitted to Higuchi model. FTIR confirmed that there was no chemical interaction between drug and excipients used in the formulation. . In vivo bioavailability studies were conducted for optimized formulation HF16 and reference standard. The optimized formulation of Atorvastatin trilayer matrix tablet was shown significant plasma concentration with extended release and maintained for 24 hrs with patient compliance by reducing the dosage frequency, when compared with reference standard. 
 
Publisher Advanced Research Journals
 
Contributor
 
Date 2016-12-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/1947
10.5138/09750215.1947
 
Source International Journal of Drug Delivery; Vol 8, No 3 (2016): International Journal of Drug Delivery; 107-116
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/1947/pdf
 
Rights Copyright (c) 2016 R Shyam sunder
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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