In Vitro - In Vivo Evaluation Of E/R Trilayer Matrix Tablets Containing Solid Dispersion Of Atorvastatin

International Journal of Drug Delivery

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Title In Vitro - In Vivo Evaluation Of E/R Trilayer Matrix Tablets Containing Solid Dispersion Of Atorvastatin
Creator Thirupathaiah, A; Osmania University Hyderabad
Sunder, R Shyam; Osmania University Hyderabad
Subject Pharmaceutical Sciences; Pharmaceutics; Drug Delivery
Atorvastatin, Carbopol 934P, Geomatrix, Trilayer matrix tablet, In-vivo bioavailability studies
Description Investigation of in vitro/in vivo behaviour of extended release tablets containing solid dispersions of Atorvastatin is the focus of the present research work. Atorvastatin trilayer matrix tablets were prepared by direct compression method and consisted of middle active layer with different grades of hydroxypropylmethylcellulose (HPMC), ethyl cellulose and Carbopol 934P. Barrier layers are prepared with hydrophobic polymers carnauba wax and xanthan gum. Based on the evaluation parameters, drug dissolution profile and release order kinetics HF16 was found to be optimized formulation. The developed drug delivery system provided prolonged drug release rates over a period of 24 h. The release profile of the optimized formulation (HF16) was described by the Zero-order and best fitted to Higuchi model. FTIR confirmed that there was no chemical interaction between drug and excipients used in the formulation. . In vivo bioavailability studies were conducted for optimized formulation HF16 and reference standard. The optimized formulation of Atorvastatin trilayer matrix tablet was shown significant plasma concentration with extended release and maintained for 24 hrs with patient compliance by reducing the dosage frequency, when compared with reference standard. 
Publisher Advanced Research Journals
Date 2016-12-08
Type info:eu-repo/semantics/article

Format application/pdf
Source International Journal of Drug Delivery; Vol 8, No 3 (2016): International Journal of Drug Delivery; 107-116
Language eng
Rights Copyright (c) 2016 R Shyam sunder

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