Preparation, characterization and evaluation of finasteride ethosomes

International Journal of Drug Delivery

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Field Value
 
Title Preparation, characterization and evaluation of finasteride ethosomes
 
Creator Sujatha, S; Department of Pharmaceutics, Mallareddy Institute of Pharmaceutical Sciences
Sowmya, G; Department of Pharmaceutics, Mallareddy Institute of Pharmaceutical Sciences
Chaitanya, M.; Department of Pharmaceutics, Mallareddy Institute of Pharmaceutical Sciences
Reddy, V S Kumar; Department of Pharmaceutics, Mallareddy College of Pharmacy
Monica, M; Department of Pharmaceutics, Mallareddy College of Pharmacy
Kumar, K Kishore; Department of Pharmaceutics, Mallareddy College of Pharmacy, Osmania University
 
Subject Pharmaceutics, Novel drug delivery, Ethosomes
Finasteride; ethosomes; SEM; FTIR
 
Description The present investigation attempted to prepare and evaluate the finasteride ethosomes for transdermal drug delivery. The ethosomal formulations were developed using different concentrations of ethanol (20-60%) and soya lecithin (1-5%). In-vitro release studies of formulation containing 30% ethanol and 3% soya lecithin showed highest % drug release (82.66%) with highest transdermal flux. The entrapment efficiency and drug content of optimized formulation were found to be 85.32% and 99.5% respectively. Scanning Electron micrographs revealed that the formed vesicles were spherical in shape with uniform size. It was also observed that concentration of the ethanol had profound influence on entrapment efficiency. The drug release from the formed vesicles was found to follow first order kinetics with higuchi diffusion mechanism. The transdermal delivery of finasteride could be potentially enhanced when they were formulated into ethosomes. This ethosomal drug delivery was found to be promising than could be a nanogel.
 
Publisher Advanced Research Journals
 
Contributor
 
Date 2016-04-18
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/1813
 
Source International Journal of Drug Delivery; Vol 8, No 1 (2016): International Journal of Drug Delivery; 01-11
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/1813/pdf
 
Rights Copyright (c) 2016 Sanneboina Sujatha, G Sowmya, M. Chaitanya, Velegala Sunil Kumar Reddy, Munigeti Monica, KISHORE KUMAR KADIMPATI
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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