EPR effect based nanocarriers targeting for treatment of cancer

International Journal of Drug Delivery

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Field Value
 
Title EPR effect based nanocarriers targeting for treatment of cancer
 
Creator Gajbhiye, Kavita Rai; Organic Chemistry Division, National Chemical Laboratory, Homi Bhabha Road, Pune
Gajbhiye, J M; Organic Chemistry Division, National Chemical Laboratory, Homi Bhabha Road, Pune
 
Subject Pharmaceutics; Drug Delivery
Enhanced permeability retention effect; Passive targeting; Tumor targeting; Nanocarrier
 
Description The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid tumors related to their anatomical and pathophysiological differences from normal tissues. In solid tumors, angiogenesis leads to high vascular density. Large gaps exist between endothelial cells in tumor blood vessels, which lead to selective extravasations and retention of macromolecular drugs. This EPR effect served as a basis for development of macromolecular anticancer therapy. There are various factors, which lead to a significantly increased EPR effect and enhanced antitumor drug effects as well. This review discusses the unique anatomy of tumor vessels, molecular mechanisms of factors related to the EPR effect and the role of the EPR effect in the intratumoral delivery of protein and peptide drugs, macromolecular drugs and drug-loaded long-circulating nanocarriers.
 
Publisher Advanced Research Journals
 
Contributor Science and Engineering Research Board (SERB), New Delhi, India for National Post Doctoral Fellowship
 
Date 2017-02-28
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://www.arjournals.org/index.php/ijdd/article/view/1974
10.5138/09750215.1974
 
Source International Journal of Drug Delivery; Vol 8, No 4 (2016): International Journal of Drug Delivery; 117-124
0975-0215
 
Language eng
 
Relation http://www.arjournals.org/index.php/ijdd/article/view/1974/pdf
 
Rights Copyright (c) 2016 Kavita Rai Gajbhiye
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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