Neutrophil recovery with or without G-CSF in non M3 AML patient with DA 3+7 protocol

Haematology Journal of Bangladesh

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Title Neutrophil recovery with or without G-CSF in non M3 AML patient with DA 3+7 protocol
Creator Islam, Gazi Yeasinul
Khan, Mohiuddin Ahmed
Akter, Mafruha
Rahman, H N Ashiqur
Ibrahim, Md.
Masud, Md. Adnan Hasan
Farhad, Md. Nurul
Rabby, A S M Tariqur
Subject neutrophil recovery
non M3 AML
DA 3 7 protocol
Description Background: Induction of acute myeloid leukaemia is associated with a high incidence of treatment related mortality mostly due to neutropenia related infections. This study primarily analyses the duration of neutrophil recovery with or without G-CSF during induction with DA 3+7 in non M3 AML patients. This study also evaluates role of G-CSF in duration febrile neutropenia, hospital stay, total blood products transfusion, total number of used injectable antibiotics and remission status. Methods: It was a Quasi Experimental - Non-Randomized Controlled Trail. There were two groups a) Case = Patients receiving G-CSF b) Control= Patients not receiving G-CSF. Sampling was purposive sampling. Results:  50 patients in two group, G-CSF group (n=25) and Control group (No G-CSF) (n=25) participated in this study. Among them 54% was female and 46% was male. Median age of the participants was 28 years. Neutrophil recovery duration in G-CSF group Vs Control group showed 22.64 Vs 24.64 days (p value 0.003). Duration of febrile neutropenia in G-CSF group Vs Control group showed 11.24 Vs 13.56 days (p value 0.038). Duration of hospital stay in G-CSF group Vs Control group showed 23.64 Vs 25.76 days (p value 0.002). Total number of blood and blood product transfusion in G-CSF group Vs Control group showed 3.80 Vs 3.88 (p value 0.597). Total number of injectable antibiotics in G-CSF group Vs Control group showed 2.72 Vs 3.12 days (p value 0.169). In G-CSF group 22 (88%) and in Control group 23 (92%) were in complete remission (p value 0.637). Conclusions: G-CSF significantly reduces the duration of neutropenia (p value 0.003), febrile neutropenia (p value 0.038) and hospital stay (p value 0.002) after induction with DA 3+7. This may cause reduction in treatment cost and sepsis related mortality. G-CSF can’t significantly reduce use of blood products (p value 0.597) and injectable antibiotics (p value 0.169) after induction with DA 3+7. G-CSF does not affect morphological remission status (p value 0.637) after induction with DA 3+7.
Publisher Haematology Society of Bangladesh
Date 2021-05-06
Type info:eu-repo/semantics/article
Peer-Reviewed Article
Format text/html
Source Haematology Journal of Bangladesh; Vol. 5 No. 01 (2021); 15-19
Language eng
Rights Copyright (c) 2020 Gazi Yeasinul Islam, Mohiuddin Ahmed Khan, Mafruha Akter, H N Ashiqur Rahman, Md. Ibrahim, Md. Adnan Hasan Masud, Md. Nurul Farhad, A S M Tariqur Rabby

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